Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folEKEGG: bsu:BSU22780 GTP cyclohydrolase I; TIGRFAM: GTP cyclohydrolase I; PFAM: GTP cyclohydrolase I. (227 aa)    
Predicted Functional Partners:
Plim_0874
TIGRFAM:2-amino-4-hydroxy-6- hydroxymethyldihydropter idinepyrophosphokinase; PFAM: 78-dihydro-6-hydroxymethylpterin- pyrophosphokinase HPPK; KEGG: sfu:Sfum_0053 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase.
  
 0.992
Plim_1925
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.967
Plim_2408
KEGG: hypothetical protein.
  
 
 0.953
Plim_4125
6-pyruvoyl tetrahydropterin synthase and hypothetical protein.
  
 
 0.953
ribA
GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. In the N-terminal section; belongs to the DHBP synthase family.
 
 
 0.948
moaA
Molybdenum cofactor biosynthesis protein A; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
    
 0.918
Plim_1695
Alkaline phosphatase; KEGG: bsu:BSU02620 phosphodiesterase/alkaline phosphatase D.
    
 0.911
Plim_3028
Phosphodiesterase/alkaline phosphatase D-like protein.
    
 0.911
Plim_3159
Alkaline phosphatase.
     
  0.900
Plim_2035
PFAM: dihydropteroate synthase DHPS; KEGG: mca:MCA1245 pterin-binding domain-containing protein.
  
  
 0.874
Your Current Organism:
Planctopirus limnophila
NCBI taxonomy Id: 521674
Other names: P. limnophila DSM 3776, Planctomyces limnophilus ATCC 43296, Planctomyces limnophilus DSM 3776, Planctomyces limnophilus str. DSM 3776, Planctomyces limnophilus strain DSM 3776, Planctopirus limnophila DSM 3776, Planctopirus limnophilus DSM 3776
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