Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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Plim_1555TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4; KEGG: dps:DP1734 uroporphyrinogen III synthase/methyltransferase (HemD+CobA). (545 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
Plim_1546
Porphobilinogen synthase; PFAM: delta-aminolevulinic acid dehydratase; KEGG: rpb:RPB_2623 delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.990
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.951
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.943
Plim_0369
Phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite.
 
  
 0.934
Plim_3055
precorrin-3B synthase; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.933
Plim_2758
Sulfite reductase (NADPH); Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.
 
  
 0.931
Plim_2288
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: sus:Acid_0761 uroporphyrinogen III synthase HEM4.
  
 
 0.922
Plim_0023
PFAM: cytochrome c assembly protein; KEGG: acp:A2cp1_1853 cytochrome c assembly protein.
  
  
 0.906
Plim_2903
Cobalamin (vitamin B12) biosynthesis CbiX protein.
 
  
 0.894
Your Current Organism:
Planctopirus limnophila
NCBI taxonomy Id: 521674
Other names: P. limnophila DSM 3776, Planctomyces limnophilus ATCC 43296, Planctomyces limnophilus DSM 3776, Planctomyces limnophilus str. DSM 3776, Planctomyces limnophilus strain DSM 3776, Planctopirus limnophila DSM 3776, Planctopirus limnophilus DSM 3776
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