Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Plim_3519Formaldehyde-activating enzyme. (211 aa)    
Predicted Functional Partners:
ffsA
Formylmethanofuran/tetrahydromethanopterin N- formyltransferase; Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT); Belongs to the FTR family.
 
  
 0.978
Plim_3754
Methylenetetrahydrofolate dehydrogenase (NADP(+)).
  
  
  0.976
Plim_1285
TIGRFAM: formaldehyde-activating enzyme; PFAM: Formaldehyde-activating enzyme (Fae); KEGG: msl:Msil_2390 formaldehyde-activating enzyme.
  
  
 
0.915
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.911
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT; Belongs to the MCH family.
 
   
 0.816
Plim_2407
PFAM: triphosphoribosyl-dephospho-CoA protein; KEGG: lch:Lcho_3148 triphosphoribosyl-dephospho-CoA protein.
 
   
 0.803
Plim_2022
PFAM: protein of unknown function DUF201; KEGG: lch:Lcho_3151 hypothetical protein.
 
   
 0.802
Plim_2423
TIGRFAM: beta-ribofuranosylaminobenzene 5'- phosphate synthase family; PFAM: GHMP kinase; KEGG: bxe:Bxe_B2430 beta-ribofuranosylaminobenzene 5'-phosphate synthase.
 
     0.790
Plim_1421
PFAM: glutamate synthase alpha subunit domain protein; KEGG: msl:Msil_2403 formylmethanofuran dehydrogenase subunit C.
 
     0.789
Plim_1687
TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase 3; KEGG: noc:Noc_0024 DNA/RNA non-specific endonuclease.
 
     0.789
Your Current Organism:
Planctopirus limnophila
NCBI taxonomy Id: 521674
Other names: P. limnophila DSM 3776, Planctomyces limnophilus ATCC 43296, Planctomyces limnophilus DSM 3776, Planctomyces limnophilus str. DSM 3776, Planctomyces limnophilus strain DSM 3776, Planctopirus limnophila DSM 3776, Planctopirus limnophilus DSM 3776
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