STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Neighborhood
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Co-occurrence
Co-expression
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[Homology]
Score
Plim_35322-oxo-acid dehydrogenase E1 subunit, homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (917 aa)    
Predicted Functional Partners:
Plim_3533
Catalytic domain of components of various dehydrogenase complexes.
 
 0.997
Plim_3309
KEGG: swi:Swit_0769 short chain dehydrogenase.
  
 0.962
Plim_3274
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 
 0.926
Plim_1786
Malate dehydrogenase (oxaloacetate- decarboxylating) (NADP(+)); PFAM: malic protein NAD-binding; malic protein domain protein; KEGG: mca:MCA1836 malate dehydrogenase.
    
 0.922
Plim_2420
KEGG: sfu:Sfum_2562 pyruvate, phosphate dikinase; TIGRFAM: pyruvate, phosphate dikinase; PFAM: pyruvate phosphate dikinase PEP/pyruvate- binding; PEP-utilising protein mobile region; PEP- utilizing protein; Belongs to the PEP-utilizing enzyme family.
     
 0.915
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
     
 0.911
Plim_1746
PFAM: Lactate/malate dehydrogenase; KEGG: aba:Acid345_1483 malate dehydrogenase (NAD); Belongs to the LDH/MDH superfamily.
     
 0.911
Plim_0621
2-oxoglutarate dehydrogenase, E2 subunit, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
  
 
 0.863
Plim_1350
PFAM: biotin/lipoyl attachment domain-containing protein; KEGG: eli:ELI_06130 pyruvate dehydrogenase E2 component.
  
 
 0.863
pgi
Glucose-6-phosphate isomerase; Belongs to the GPI family.
  
 
 0.856
Your Current Organism:
Planctopirus limnophila
NCBI taxonomy Id: 521674
Other names: P. limnophila DSM 3776, Planctomyces limnophilus ATCC 43296, Planctomyces limnophilus DSM 3776, Planctomyces limnophilus str. DSM 3776, Planctomyces limnophilus strain DSM 3776, Planctopirus limnophila DSM 3776, Planctopirus limnophilus DSM 3776
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