node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | M231_00038 | A0A4Q1BIT1 | A0A4Q1BWD6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.751 |
FEN1 | M231_00153 | A0A4Q1BIT1 | A0A4Q1BWP6 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ubiquitin-like domain-containing protein. | 0.474 |
FEN1 | M231_02176 | A0A4Q1BIT1 | A0A4Q1BRE1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ku domain-containing protein. | 0.683 |
FEN1 | M231_02767 | A0A4Q1BIT1 | A0A4Q1BQ94 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | POLAc domain-containing protein. | 0.576 |
FEN1 | M231_06922 | A0A4Q1BIT1 | A0A4Q1BAM0 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.746 |
FEN1 | M231_06941 | A0A4Q1BIT1 | A0A4Q1BAJ1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Uncharacterized protein. | 0.612 |
FEN1 | M231_07455 | A0A4Q1BIT1 | A0A4Q1BC75 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | VWFA domain-containing protein. | 0.622 |
M231_00038 | FEN1 | A0A4Q1BWD6 | A0A4Q1BIT1 | Uncharacterized protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.751 |
M231_00038 | M231_00153 | A0A4Q1BWD6 | A0A4Q1BWP6 | Uncharacterized protein. | Ubiquitin-like domain-containing protein. | 0.730 |
M231_00038 | M231_00225 | A0A4Q1BWD6 | A0A4Q1BJT3 | Uncharacterized protein. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.835 |
M231_00038 | M231_01368 | A0A4Q1BWD6 | A0A4Q1BTA4 | Uncharacterized protein. | Uncharacterized protein. | 0.751 |
M231_00038 | M231_02176 | A0A4Q1BWD6 | A0A4Q1BRE1 | Uncharacterized protein. | Ku domain-containing protein. | 0.811 |
M231_00038 | M231_02767 | A0A4Q1BWD6 | A0A4Q1BQ94 | Uncharacterized protein. | POLAc domain-containing protein. | 0.729 |
M231_00038 | M231_04294 | A0A4Q1BWD6 | A0A4Q1BKU7 | Uncharacterized protein. | EF-hand calcium-binding protein. | 0.754 |
M231_00038 | M231_06922 | A0A4Q1BWD6 | A0A4Q1BAM0 | Uncharacterized protein. | Uncharacterized protein. | 0.731 |
M231_00038 | M231_06941 | A0A4Q1BWD6 | A0A4Q1BAJ1 | Uncharacterized protein. | Uncharacterized protein. | 0.759 |
M231_00038 | M231_07455 | A0A4Q1BWD6 | A0A4Q1BC75 | Uncharacterized protein. | VWFA domain-containing protein. | 0.841 |
M231_00153 | FEN1 | A0A4Q1BWP6 | A0A4Q1BIT1 | Ubiquitin-like domain-containing protein. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.474 |
M231_00153 | M231_00038 | A0A4Q1BWP6 | A0A4Q1BWD6 | Ubiquitin-like domain-containing protein. | Uncharacterized protein. | 0.730 |
M231_00153 | M231_00225 | A0A4Q1BWP6 | A0A4Q1BJT3 | Ubiquitin-like domain-containing protein. | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | 0.861 |