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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ACV35205.1TIGRFAM: isochorismate synthase; PFAM: Chorismate binding-like; KEGG: dar:Daro_2823 isochorismate synthase. (470 aa)    
Predicted Functional Partners:
menD
2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). Belongs to the TPP enzyme family. MenD subfamily.
 
 0.997
ACV34486.1
TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I; KEGG: dar:Daro_3477 anthranilate synthase component II.
  
 
  0.941
ACV36183.1
TIGRFAM: chorismate mutase; PFAM: prephenate dehydratase; Chorismate mutase; amino acid-binding ACT domain protein; KEGG: dar:Daro_1232 prephenate dehydratase.
  
 
 0.919
ubiC
Chorismate lyase; Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4-hydroxybenzoate (4HB) for the ubiquinone pathway; Belongs to the UbiC family.
     
 0.914
aroC
Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.904
ACV36592.1
PFAM: isochorismatase hydrolase; KEGG: pmy:Pmen_3537 isochorismatase hydrolase.
  
  
 0.904
ACV33696.1
KEGG: dar:Daro_4196 endoribonuclease L-PSP.
     
  0.900
ACV35204.1
PFAM: AMP-dependent synthetase and ligase; KEGG: dar:Daro_2822 AMP-dependent synthetase and ligase.
 
   
 0.891
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
  
  
0.877
ACV35623.1
Aspartate transaminase; PFAM: aminotransferase class I and II; KEGG: eba:ebA5437 aromatic amino acid aminotransferase.
     
 0.829
Your Current Organism:
Accumulibacter phosphatis
NCBI taxonomy Id: 522306
Other names: Accumulibacter phosphatis UW-1, C. Accumulibacter phosphatis clade IIA str. UW-1, Candidatus Accumulibacter phosphatis Type IIA str. UW-1, Candidatus Accumulibacter phosphatis clade IIA str. UW-1, Candidatus Accumulibacter phosphatis clade IIA strain UW-1
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