node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACV34571.1 | ACV35139.1 | CAP2UW1_1243 | CAP2UW1_1839 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.998 |
ACV34571.1 | ACV35140.1 | CAP2UW1_1243 | CAP2UW1_1840 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: bja:blr3722 dihydrolipoamide dehydrogenase. | 0.999 |
ACV34571.1 | ACV35679.1 | CAP2UW1_1243 | CAP2UW1_2390 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: azo:azo1557 dihydrolipoamide dehydrogenase. | 0.999 |
ACV34571.1 | ACV37490.1 | CAP2UW1_1243 | CAP2UW1_4249 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: bam:Bamb_1974 dihydrolipoamide dehydrogenase. | 0.999 |
ACV34571.1 | gcvH | CAP2UW1_1243 | CAP2UW1_1959 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.882 |
ACV34571.1 | gcvP | CAP2UW1_1243 | CAP2UW1_1958 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.552 |
ACV34571.1 | gcvT | CAP2UW1_1243 | CAP2UW1_1960 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.836 |
ACV34571.1 | glyA | CAP2UW1_1243 | CAP2UW1_1498 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.707 |
ACV34571.1 | lipA | CAP2UW1_1243 | CAP2UW1_0704 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.626 |
ACV34571.1 | lipB | CAP2UW1_1243 | CAP2UW1_0703 | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.589 |
ACV35139.1 | ACV34571.1 | CAP2UW1_1839 | CAP2UW1_1243 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | PFAM: biotin/lipoyl attachment domain-containing protein; dehydrogenase E1 component; Transketolase central region; Transketolase domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III; KEGG: plu:plu1883 hypothetical protein. | 0.998 |
ACV35139.1 | ACV35140.1 | CAP2UW1_1839 | CAP2UW1_1840 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: bja:blr3722 dihydrolipoamide dehydrogenase. | 0.997 |
ACV35139.1 | ACV35679.1 | CAP2UW1_1839 | CAP2UW1_2390 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase; KEGG: azo:azo1557 dihydrolipoamide dehydrogenase. | 0.996 |
ACV35139.1 | ACV37490.1 | CAP2UW1_1839 | CAP2UW1_4249 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; KEGG: bam:Bamb_1974 dihydrolipoamide dehydrogenase. | 0.988 |
ACV35139.1 | gcvH | CAP2UW1_1839 | CAP2UW1_1959 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.873 |
ACV35139.1 | gcvP | CAP2UW1_1839 | CAP2UW1_1958 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.633 |
ACV35139.1 | gcvT | CAP2UW1_1839 | CAP2UW1_1960 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.685 |
ACV35139.1 | glyA | CAP2UW1_1839 | CAP2UW1_1498 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.406 |
ACV35139.1 | lipA | CAP2UW1_1839 | CAP2UW1_0704 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.573 |
ACV35139.1 | lipB | CAP2UW1_1839 | CAP2UW1_0703 | Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.581 |