node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CANINC_000399 | CANINC_001496 | A0A4T0X6C6 | A0A4T0X5B5 | Uncharacterized protein. | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 0.621 |
CANINC_000399 | CANINC_003029 | A0A4T0X6C6 | A0A4T0X043 | Uncharacterized protein. | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. | 0.461 |
CANINC_000399 | CANINC_004252 | A0A4T0X6C6 | A0A4T0WXU2 | Uncharacterized protein. | ABC1 domain-containing protein. | 0.577 |
CANINC_000399 | COQ2 | A0A4T0X6C6 | A0A4T0X677 | Uncharacterized protein. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.724 |
CANINC_000399 | COQ3 | A0A4T0X6C6 | A0A4T0X2I8 | Uncharacterized protein. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.471 |
CANINC_000399 | COQ4 | A0A4T0X6C6 | A0A4T0X695 | Uncharacterized protein. | Ubiquinone biosynthesis protein COQ4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.480 |
CANINC_000399 | COQ5 | A0A4T0X6C6 | A0A4T0X003 | Uncharacterized protein. | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). | 0.485 |
CANINC_000399 | COQ6 | A0A4T0X6C6 | A0A4T0X729 | Uncharacterized protein. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.464 |
CANINC_000399 | COQ7 | A0A4T0X6C6 | A0A4T0WV20 | Uncharacterized protein. | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. | 0.473 |
CANINC_001340 | COQ4 | A0A4T0X5H6 | A0A4T0X695 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. | Ubiquinone biosynthesis protein COQ4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.482 |
CANINC_001496 | CANINC_000399 | A0A4T0X5B5 | A0A4T0X6C6 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | Uncharacterized protein. | 0.621 |
CANINC_001496 | CANINC_003029 | A0A4T0X5B5 | A0A4T0X043 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. | 0.513 |
CANINC_001496 | CANINC_004252 | A0A4T0X5B5 | A0A4T0WXU2 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | ABC1 domain-containing protein. | 0.801 |
CANINC_001496 | COQ2 | A0A4T0X5B5 | A0A4T0X677 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.527 |
CANINC_001496 | COQ3 | A0A4T0X5B5 | A0A4T0X2I8 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.711 |
CANINC_001496 | COQ4 | A0A4T0X5B5 | A0A4T0X695 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | Ubiquinone biosynthesis protein COQ4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. | 0.735 |
CANINC_001496 | COQ5 | A0A4T0X5B5 | A0A4T0X003 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; Methyltransferase required for the conversion of 2- polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl- 6-methoxy-1,4-benzoquinol (DMQH2). | 0.738 |
CANINC_001496 | COQ6 | A0A4T0X5B5 | A0A4T0X729 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.754 |
CANINC_001496 | COQ7 | A0A4T0X5B5 | A0A4T0WV20 | Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. | 5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. | 0.947 |
CANINC_003029 | CANINC_000399 | A0A4T0X043 | A0A4T0X6C6 | Uncharacterized protein; Belongs to the FPP/GGPP synthase family. | Uncharacterized protein. | 0.461 |