Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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ADD69027.1ATPase AAA-2 domain protein; KEGG: ATP-dependent clp protease ATP-binding subunit; PFAM: ATPase AAA-2 domain protein; Clp ATPase-like; AAA ATPase central domain protein; Torsin; ATPase associated with various cellular activities AAA_5; Clp domain protein; SMART: AAA ATPase; Belongs to the ClpA/ClpB family. (802 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease, proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
 
 
 0.935
ADD67342.1
KEGG: sat:SYN_01836 MreB-like ATPase involved in cell division.
  
 
 0.871
ADD67453.1
KEGG: sat:SYN_01836 MreB-like ATPase involved in cell division.
  
 
 0.871
ADD69479.1
PFAM: Heat shock protein 70; KEGG: sat:SYN_01983 chaperone protein.
  
 
 0.871
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.871
ADD69028.1
KEGG: rpa:RPA4562 putative 2-dehydropantoate 2- reductase; TIGRFAM: 2-dehydropantoate 2-reductase; PFAM: Ketopantoate reductase ApbA/PanE domain protein; NUDIX hydrolase.
 
  
 0.870
grpE
GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent i [...]
  
 
 0.840
htpG
Heat shock protein Hsp90; Molecular chaperone. Has ATPase activity.
  
 
 0.785
ADD67836.1
PFAM: heat shock protein Hsp20; KEGG: maq:Maqu_3394 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.706
ADD68265.1
PFAM: heat shock protein Hsp20; KEGG: dol:Dole_2643 heat shock protein HSP20; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.706
Your Current Organism:
Denitrovibrio acetiphilus
NCBI taxonomy Id: 522772
Other names: D. acetiphilus DSM 12809, Denitrovibrio acetiphilus DSM 12809, Denitrovibrio acetiphilus N2460, Denitrovibrio acetiphilus str. DSM 12809, Denitrovibrio acetiphilus strain DSM 12809
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