Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (326 aa)    
Predicted Functional Partners:
ADD68566.1
KEGG: glo:Glov_1379 type I citrate synthase; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.998
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
  
 0.988
ADD68300.1
PFAM: malic protein NAD-binding; malic protein domain protein; phosphate acetyl/butaryl transferase; KEGG: geo:Geob_2882 malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)), phosphate acetyltransferase.
  
 0.980
ADD69109.1
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; KEGG: ade:Adeh_2227 isocitrate dehydrogenase, NADP- dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; Belongs to the monomeric-type IDH family.
  
  
 0.976
ADD69121.1
TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; KEGG: acp:A2cp1_0286 Fe-S type hydro-lyase tartrate/fumarate beta region; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region.
  
 
 0.970
ADD69120.1
KEGG: dma:DMR_34300 L-tartrate dehydratase alpha subunit; TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate alpha region.
  
 
 0.969
ADD67988.1
Malate dehydrogenase (oxaloacetate- decarboxylating); KEGG: gsu:GSU2308 malate oxidoreductase; PFAM: malic protein domain protein; malic protein NAD-binding.
  
 0.955
ADD69092.1
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.955
ADD68791.1
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.948
pckA
Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.
  
 
 0.941
Your Current Organism:
Denitrovibrio acetiphilus
NCBI taxonomy Id: 522772
Other names: D. acetiphilus DSM 12809, Denitrovibrio acetiphilus DSM 12809, Denitrovibrio acetiphilus N2460, Denitrovibrio acetiphilus str. DSM 12809, Denitrovibrio acetiphilus strain DSM 12809
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