Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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[Homology]
Score
ADD69361.1PFAM: Xanthine/uracil/vitamin C permease; KEGG: lhk:LHK_00455 probable membrane permease protein. (444 aa)    
Predicted Functional Partners:
ade
TIGRFAM: adenine deaminase; KEGG: sun:SUN_0856 adenine deaminase; PFAM: amidohydrolase; Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.
     
 0.801
ADD68923.1
KEGG: vpa:VP2283 uracil permease; TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease.
 
  
 0.743
purD
KEGG: dps:DP2188 phosphoribosylamine--glycine ligase; TIGRFAM: phosphoribosylamine/glycine ligase; PFAM: phosphoribosylglycinamide synthetase; Belongs to the GARS family.
  
  
 0.646
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.627
purM
TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; KEGG: pca:Pcar_1293 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.
  
  
 0.625
purQ
Phosphoribosylformylglycinamidine synthase I; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...]
  
  
 0.608
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
  
  
 0.597
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.584
purC
TIGRFAM: phosphoribosylaminoimidazole- succinocarboxamide synthase; KEGG: gur:Gura_2868 phosphoribosylaminoimidazole- succinocarboxamide synthase; PFAM: SAICAR synthetase.
  
  
 0.583
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.520
Your Current Organism:
Denitrovibrio acetiphilus
NCBI taxonomy Id: 522772
Other names: D. acetiphilus DSM 12809, Denitrovibrio acetiphilus DSM 12809, Denitrovibrio acetiphilus N2460, Denitrovibrio acetiphilus str. DSM 12809, Denitrovibrio acetiphilus strain DSM 12809
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