Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ADD69558.1PFAM: aminotransferase class-III; KEGG: gsu:GSU0337 glutamate-1-semialdehyde aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (429 aa)    
Predicted Functional Partners:
ADD69660.1
Porphobilinogen synthase; KEGG: gme:Gmet_0189 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 
 0.990
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
 0.984
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: gur:Gura_4245 glutamate-1-semialdehyde aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III.
  
  
 
0.922
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.895
ADD69557.1
PFAM: protein of unknown function DUF72; KEGG: apa:APP7_1262 hypothetical protein.
       0.788
ADD69559.1
KEGG: cco:CCC13826_0839 FlhB domain-containing protein.
       0.717
ADD67963.1
PFAM: AMP-dependent synthetase and ligase; KEGG: nam:NAMH_1365 long-chain-fatty-acid--CoA ligase.
  
 0.622
ADD67246.1
PFAM: acylneuraminate cytidylyltransferase; KEGG: rpf:Rpic12D_0583 acylneuraminate cytidylyltransferase.
      0.608
ADD69659.1
Uroporphyrinogen III synthase HEM4; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
  
 0.565
guaA
GMP synthase, large subunit; Catalyzes the synthesis of GMP from XMP.
     
 0.536
Your Current Organism:
Denitrovibrio acetiphilus
NCBI taxonomy Id: 522772
Other names: D. acetiphilus DSM 12809, Denitrovibrio acetiphilus DSM 12809, Denitrovibrio acetiphilus N2460, Denitrovibrio acetiphilus str. DSM 12809, Denitrovibrio acetiphilus strain DSM 12809
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