Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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thiCThiamine biosynthesis protein ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (423 aa)    
Predicted Functional Partners:
ADD66848.1
KEGG: cja:CJA_2910 phosphomethylpyrimidine kinase; TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1.
 
 
 0.995
thiG
Thiazole biosynthesis family protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
 0.985
thiE
Thiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family.
 
  
 0.967
ADD69294.1
KEGG: sfu:Sfum_1822 thiamine biosynthesis protein ThiH; TIGRFAM: thiazole biosynthesis protein ThiH; PFAM: biotin and thiamin synthesis associated; Radical SAM domain protein.
  
 0.935
ADD67888.1
PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; KEGG: aeh:Mlg_1160 molybdopterin biosynthesis protein MoeB.
 
  
 0.845
ADD66852.1
KEGG: pst:PSPTO_0433 sulfur carrier protein ThiS; TIGRFAM: thiamine biosynthesis protein ThiS; PFAM: thiamineS protein.
  
  
 0.832
ADD68432.1
PFAM: thiamineS protein.
  
  
 0.832
ADD69520.1
PFAM: thiamine monophosphate synthase; KEGG: hhe:HH1498 hypothetical protein.
  
  
 0.818
thiL
Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family.
     
 0.811
purM
TIGRFAM: phosphoribosylformylglycinamidine cyclo- ligase; KEGG: pca:Pcar_1293 phosphoribosylaminoimidazole synthetase; PFAM: AIR synthase related protein; AIR synthase related protein domain protein.
    
 0.809
Your Current Organism:
Denitrovibrio acetiphilus
NCBI taxonomy Id: 522772
Other names: D. acetiphilus DSM 12809, Denitrovibrio acetiphilus DSM 12809, Denitrovibrio acetiphilus N2460, Denitrovibrio acetiphilus str. DSM 12809, Denitrovibrio acetiphilus strain DSM 12809
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