STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EHY69922.1Type III secretion chaperone domain protein; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM1090; pipC. (113 aa)    
Predicted Functional Partners:
sopB
Enterobacterial virulence protein; Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enl [...]
  
  
 0.983
sopE2
SopE GEF domain protein; Locus tag in AE006468 is STM1855; sopE2.
   
    0.850
prgI
Type III secretion apparatus needle protein; Locus tag in AE006468 is STM2873; prgI.
   
    0.674
EHY68439.1
Type III effector protein IpaD/SipD/SspD; Locus tag in AE006468 is STM2883; sipD.
   
    0.674
EHY68438.1
Hypothetical protein; Locus tag in AE006468 is STM2882; sipA.
   
    0.672
iacP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
   
    0.669
sicA
Type III secretion low calcium response chaperone LcrH/SycD; Locus tag in AE006468 is STM2886; sicA.
   
    0.655
sipB
Hypothetical protein; Locus tag in AE006468 is STM2885; sipB.
   
    0.618
sopE
SopE GEF domain protein; Activator for both CDC42 and RAC1 by directly engaging these Rho GTPases and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non- phagocytic cells (By similarity).
   
    0.607
EHY68440.1
Type III secretion target, IpaC/SipC family; Locus tag in AE006468 is STM2884; sipC.
   
    0.579
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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