STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
hisHImidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (196 aa)    
Predicted Functional Partners:
hisB
Histidinol-phosphatase; KEGG: sea:SeAg_B2199 2.4e-189 hisB; imidazole glycerol-phosphate dehydratase/histidinol phosphatase K01089; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2074; hisB; In the N-terminal section; belongs to the histidinol- phosphatase family.
 
 
 0.999
hisA
KEGG: see:SNSL254_A2255 7.9e-120 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase K01814; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2076; hisA.
 
 0.999
hisF
Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
 0.999
hisI
phosphoribosyl-ATP diphosphatase; KEGG: sew:SeSA_A2306 7.9e-104 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein K11755; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2078; hisI; In the N-terminal section; belongs to the PRA-CH family.
 
 
 0.999
EHY71106.1
KEGG: gur:Gura_1692 2.6e-82 imidazole glycerol phosphate synthase subunit HisF; K02500 cyclase HisF; Psort location: Cytoplasmic, score: 9.26.
 0.999
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
 0.998
hisC
KEGG: spq:SPAB_00960 1.2e-187 histidinol-phosphate aminotransferase; K00817 histidinol-phosphate aminotransferase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2073; hisC; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
 
 
 0.993
hisG
ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.
 
  
 0.991
EHY71107.1
KEGG: vvy:VV0355 1.5e-61 hisH; imidazole glycerol phosphate synthase subunit HisH; K02501 glutamine amidotransferase; Psort location: Cytoplasmic, score: 9.26.
  
  
 
0.917
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Locus tag in AE006468 is STM4176; purH.
    
 0.722
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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