STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseBsigma-E factor regulatory protein RseB; Psort location: Periplasmic, score: 9.76; locus tag in AE006468 is STM2638; rseB. (318 aa)    
Predicted Functional Partners:
rseA
Anti sigma-E protein RseA protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
 
 
 0.999
rseC
Positive regulator of sigma(E), RseC/MucC; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM2637; rseC.
 
  
 0.996
rpoE
KEGG: reh:H16_A2563 2.3e-58 rpoE1; RNA polymerase sigma factor RpoE K03088; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2640; rpoE; Belongs to the sigma-70 factor family. ECF subfamily.
 
 
 0.951
rseP
RIP metalloprotease RseP; KEGG: seg:SG0227 5.0e-237 yaeL; zinc metallopeptidase RseP; K11749 regulator of sigma E protease; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM0223; yaeL.
  
  
 0.881
degS
Periplasmic serine peptidase DegS; KEGG: ses:SARI_04275 3.0e-182 serine endoprotease; K04691 serine protease DegS; locus tag in AE006468 is STM3349; degS.
  
  
 0.840
EHY69257.1
Methyltransferase domain protein; KEGG: vfi:VF_1937 1.2e-45 yafS; S-adenosyl-L-methionine-dependent methyltransferase K00599; locus tag in AE006468 is STM0262; yafS.
  
     0.730
seqA
SeqA protein; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
  
     0.713
lptC
Hypothetical protein; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.689
lapA
Putative inner membrane protein; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.673
SBOV23001
Hypothetical protein; Locus tag in AE006468 is STM2227; yejL; Belongs to the UPF0352 family.
  
     0.624
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.