STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
corEKEGG: rsa:RSal33209_2705 1.1e-05 resC; apocytochrome heme-lyase; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM2678; corE. (263 aa)    
Predicted Functional Partners:
EHY68379.1
Beta-phosphoglucomutase family hydrolase; KEGG: eci:UTI89_C3052 8.7e-82 yqaB; fructose-1-phosphatase; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2820; yqaB.
      
 0.809
dsbC
Putative thiol:disulfide interchange protein DsbC; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.
 
     0.718
EHY69368.1
Hypothetical protein; KEGG: hip:CGSHiEE_02470 1.2e-15 pflA; pyruvate formate lyase-activating enzyme 1 K07286; locus tag in AE006468 is STM0445; yajG.
  
     0.696
slyX
SlyX protein; Locus tag in AE006468 is STM3454; slyX; Belongs to the SlyX family.
  
   
 0.696
yfjD
Transporter associated domain protein; KEGG: ece:Z3906m 4.0e-203 yfjD; hypothetical protein; K00638 chloramphenicol O-acetyltransferase; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM2679; yfjD.
  
    0.647
EHY69257.1
Methyltransferase domain protein; KEGG: vfi:VF_1937 1.2e-45 yafS; S-adenosyl-L-methionine-dependent methyltransferase K00599; locus tag in AE006468 is STM0262; yafS.
  
     0.639
bamE
SmpA / OmlA family protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
    0.602
yciU
Hypothetical protein; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM1740; yciU; Belongs to the UPF0263 family.
  
     0.593
ffh
Signal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual componen [...]
       0.583
rseA
Anti sigma-E protein RseA protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
  
     0.568
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.