STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
luxSS-ribosylhomocysteinase LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (171 aa)    
Predicted Functional Partners:
mtnN
MTA/SAH nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Also cleaves 5'-deoxyadenosine, a toxic by-product of radical S-adenosylmethionine (SAM) enzymes, into 5-deoxyribose and adenine. Thus, is required for in vivo function of the radical SAM enzymes biotin synthase and lipoic acid synthase, that are inhibited by 5'-deoxyadenosine accumulation. Belongs to the PNP/UDP phosphorylas [...]
 
 
 0.999
EHY67160.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
 0.998
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
    
 0.996
metC
Cystathionine beta-lyase; KEGG: sea:SeAg_B3335 3.0e-207 metC; cystathionine beta-lyase K01760; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3161; metC.
 
 
 0.994
EHY67714.1
O-succinylhomoserine (thiol)-lyase; KEGG: sew:SeSA_A4317 3.7e-200 metB; cystathionine gamma-synthase K01739; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4100; metB.
 
 
 0.994
EHY69381.1
Pyridoxal-phosphate dependent enzyme; KEGG: set:SEN0440 3.4e-190 putative lyase; K01738 cysteine synthase A; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0458.
  
 
 0.936
cysK
Cysteine synthase A; KEGG: see:SNSL254_A2623 1.7e-165 cysK; cysteine synthase A K01738; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM2430; cysK; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.936
thrA
Homoserine dehydrogenase; KEGG: set:SEN0001 0. thrA; bifunctional aspartokinase I/homeserine dehydrogenase I; K12524 bifunctional aspartokinase/homoserine dehydrogenase 1; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0002; thrA; In the C-terminal section; belongs to the homoserine dehydrogenase family.
     
 0.934
metL
Homoserine dehydrogenase; KEGG: sty:STY3768 0. metL, metM; bifunctional aspartate kinase II/homoserine dehydrogenase II K12525; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM4101; metL; In the C-terminal section; belongs to the homoserine dehydrogenase family.
     
 0.934
EHY68849.1
Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
 0.914
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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