STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EHY68564.1KEGG: ses:SARI_04656 0. fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; K08484 phosphotransferase system, enzyme I, PtsP; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3003; ptsP; Belongs to the PEP-utilizing enzyme family. (748 aa)    
Predicted Functional Partners:
ptsO
Phosphocarrier, HPr family; KEGG: aha:AHA_3919 1.3e-30 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) K08485; locus tag in AE006468 is STM3324; ptsO.
  
 
 0.999
fruB
Phosphocarrier, HPr family; KEGG: seh:SeHA_C2442 6.4e-189 fruB; bifunctional fructose-specific PTS IIA/HPr protein; K02768 PTS system, fructose-specific IIA component K11183; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM2206; fruF.
 
 
 0.970
crr
KEGG: stt:t0424 1.4e-83 crr; glucose-specific PTS system component; K02777 PTS system, glucose-specific IIA component; Psort location: Cytoplasmic, score: 10.00; locus tag in AE006468 is STM2433; crr.
 
   
 0.874
ptsH
Phosphocarrier protein HPr; KEGG: ebr:ECB_02315 1.9e-38 ptsH; phosphohistidinoprotein-hexose phosphotransferase component of PTS system (HPr) K02784; Psort location: Cytoplasmic, score: 10.00; locus tag in AE006468 is STM2431; ptsH.
  
 
 0.848
rppH
RNA pyrophosphohydrolase; Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage; Belongs to the Nudix hydrolase family. RppH subfamily.
  
 
 0.832
ptsN
KEGG: see:SNSL254_A3583 1.0e-80 ptsN; PTS IIA-like nitrogen-regulatory protein PtsN; K02806 PTS system, nitrogen regulatory IIA component; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3322; ptsN.
  
   
 0.794
EHY67160.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
    
  0.762
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
       0.753
lgt
Prolipoprotein diacylglyceryl transferase; Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family.
       0.753
EHY68563.1
Hypothetical protein.
       0.715
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.