STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EHY68245.1HemX protein; KEGG: sew:SeSA_A4149 2.1e-190 putative uroporphyrinogen III C-methyltransferase; K02496 uroporphyrin-III C-methyltransferase; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM3936; hemX. (385 aa)    
Predicted Functional Partners:
EHY68246.1
uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.999
cobA
uroporphyrinogen-III C-methyltransferase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family.
     
 0.995
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
     
 0.990
hemY
HemY protein; KEGG: stm:STM3935 8.5e-210 hemY; putative protoheme IX biogenesis protein K02498; Psort location: CytoplasmicMembrane, score: 10.00; locus tag in AE006468 is STM3935; hemY.
 
  
 0.986
hemC
Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 
 0.881
lolB
Outer membrane lipoprotein LolB; Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein.
  
     0.730
cyaA
KEGG: ses:SARI_03713 0. cyaA; adenylate cyclase; K05851 adenylate cyclase, class 1; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3939; cyaA; Belongs to the adenylyl cyclase class-1 family.
 
     0.721
rseA
Anti sigma-E protein RseA protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases [...]
  
     0.670
EHY69558.1
KEGG: spq:SPAB_02904 3.8e-175 holA; DNA polymerase III subunit delta; K02340 DNA polymerase III subunit delta; locus tag in AE006468 is STM0646; holA.
  
     0.665
rseB
sigma-E factor regulatory protein RseB; Psort location: Periplasmic, score: 9.76; locus tag in AE006468 is STM2638; rseB.
  
     0.616
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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