STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metFKEGG: stt:t3511 5.8e-156 metF; 5,10-methylenetetrahydrofolate reductase K00297; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM4105; metF. (296 aa)    
Predicted Functional Partners:
EHY67160.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
 
 0.999
folD
Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.993
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.993
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
    
 0.992
nifJ
KEGG: sew:SeSA_A1770 0. nifJ; pyruvate:ferredoxin (flavodoxin) oxidoreductase K03737; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM1651; nifJ.
    
 0.985
metE
5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
 
 0.985
metR
KEGG: spl:Spea_0904 1.7e-15 LysR family transcriptional regulator; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM3964; metR; Belongs to the LysR transcriptional regulatory family.
   
  
 0.967
thrA
Homoserine dehydrogenase; KEGG: set:SEN0001 0. thrA; bifunctional aspartokinase I/homeserine dehydrogenase I; K12524 bifunctional aspartokinase/homoserine dehydrogenase 1; Psort location: Cytoplasmic, score: 8.96; locus tag in AE006468 is STM0002; thrA; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.946
metL
Homoserine dehydrogenase; KEGG: sty:STY3768 0. metL, metM; bifunctional aspartate kinase II/homoserine dehydrogenase II K12525; Psort location: CytoplasmicMembrane, score: 9.82; locus tag in AE006468 is STM4101; metL; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.946
EHY67714.1
O-succinylhomoserine (thiol)-lyase; KEGG: sew:SeSA_A4317 3.7e-200 metB; cystathionine gamma-synthase K01739; Psort location: Cytoplasmic, score: 9.97; locus tag in AE006468 is STM4100; metB.
 
 0.938
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.