STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
btuBTonB-dependent vitamin B12 receptor; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. (614 aa)    
Predicted Functional Partners:
btuF
Periplasmic binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC.
 
  
 0.895
tonB
Gram-negative bacterial TonB protein; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 
 0.886
btuC
Iron chelate uptake ABC transporter, FeCT family, permease protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane.
 
   
 0.868
ompC_1
Psort location: OuterMembrane, score: 10.00; locus tag in AE006468 is STM2267; ompC; Belongs to the Gram-negative porin family.
    
 0.859
btuD
ABC transporter, ATP-binding protein; Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system.
  
   
 0.844
ompF
Outer membrane protein; KEGG: hip:CGSHiEE_02590 0.00018 nagA; N-acetylglucosamine-6-phosphate deacetylase; Psort location: OuterMembrane, score: 10.00; locus tag in AE006468 is STM0999; ompF; Belongs to the Gram-negative porin family.
    
 0.802
ompA
Outer membrane protein A; KEGG: rcm:A1E_04945 9.1e-06 gmk; guanylate kinase K03640; Psort location: OuterMembrane, score: 10.00; locus tag in AE006468 is STM1070; ompA; Belongs to the outer membrane OOP (TC 1.B.6) superfamily.
  
  
 0.720
EHY67160.1
Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
 
   
 0.687
lamB
LamB porin; Involved in the transport of maltose and maltodextrins. Belongs to the porin LamB (TC 1.B.3) family.
     
 0.681
bcsQ
Cellulose synthase operon protein YhjQ; Locus tag in AE006468 is STM3620; yhjQ.
  
 
 
 0.680
Your Current Organism:
Salmonella enterica houtenae
NCBI taxonomy Id: 523831
Other names: S. enterica subsp. houtenae str. ATCC BAA-1581, Salmonella enterica subsp. houtenae str. ATCC BAA-1581
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.