STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdaDPyruvoyl-dependent arginine decarboxylase. (157 aa)    
Predicted Functional Partners:
speB1
Agmatinase; Belongs to the arginase family.
    
 0.947
speB
Arginase; Belongs to the arginase family.
    
 0.917
argH
Argininosuccinate lyase.
     
  0.800
speE
Spermidine synthase; Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.
  
  
 0.644
psmR-2
Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...]
       0.622
HFX_2054
Hypothetical protein.
       0.582
usp14
Universal stress protein.
  
     0.542
HFX_1883
Hypothetical protein.
  
     0.531
hmgR
hydroxymethylglutaryl-CoA reductase (NADPH) / 3-hydroxy-3-methylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family.
      
 0.529
HFX_2053
Histidine kinase.
       0.514
Your Current Organism:
Haloferax mediterranei
NCBI taxonomy Id: 523841
Other names: H. mediterranei ATCC 33500, Haloferax mediterranei ATCC 33500, Haloferax mediterranei CGMCC 1.2087, Haloferax mediterranei JCM 8866, Haloferax mediterranei R-4, Haloferax mediterranei str. ATCC 33500, Haloferax mediterranei strain ATCC 33500
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.