node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMH29800.1 | SMH32238.1 | SAMN06264941_0236 | SAMN06264941_0543 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | TP53 regulating kinase. | 0.848 |
SMH29800.1 | SMH32247.1 | SAMN06264941_0236 | SAMN06264941_0544 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | O-sialoglycoprotein endopeptidase. | 0.872 |
SMH29800.1 | valS | SAMN06264941_0236 | SAMN06264941_0692 | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.483 |
SMH32235.1 | SMH32238.1 | SAMN06264941_0542 | SAMN06264941_0543 | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | TP53 regulating kinase. | 0.679 |
SMH32235.1 | SMH32247.1 | SAMN06264941_0542 | SAMN06264941_0544 | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | O-sialoglycoprotein endopeptidase. | 0.679 |
SMH32235.1 | infB | SAMN06264941_0542 | SAMN06264941_0112 | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Translation initiation factor eaIF-5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. | 0.440 |
SMH32235.1 | valS | SAMN06264941_0542 | SAMN06264941_0692 | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.482 |
SMH32238.1 | SMH29800.1 | SAMN06264941_0543 | SAMN06264941_0236 | TP53 regulating kinase. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.848 |
SMH32238.1 | SMH32235.1 | SAMN06264941_0543 | SAMN06264941_0542 | TP53 regulating kinase. | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.679 |
SMH32238.1 | SMH32247.1 | SAMN06264941_0543 | SAMN06264941_0544 | TP53 regulating kinase. | O-sialoglycoprotein endopeptidase. | 0.989 |
SMH32238.1 | SMH38062.1 | SAMN06264941_0543 | SAMN06264941_1217 | TP53 regulating kinase. | KEOPS complex subunit Cgi121. | 0.815 |
SMH32238.1 | infB | SAMN06264941_0543 | SAMN06264941_0112 | TP53 regulating kinase. | Translation initiation factor eaIF-5B; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. | 0.525 |
SMH32238.1 | pheS | SAMN06264941_0543 | SAMN06264941_1295 | TP53 regulating kinase. | phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. | 0.400 |
SMH32238.1 | valS | SAMN06264941_0543 | SAMN06264941_0692 | TP53 regulating kinase. | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.653 |
SMH32247.1 | SMH29800.1 | SAMN06264941_0544 | SAMN06264941_0236 | O-sialoglycoprotein endopeptidase. | Translation factor SUA5; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | 0.872 |
SMH32247.1 | SMH32235.1 | SAMN06264941_0544 | SAMN06264941_0542 | O-sialoglycoprotein endopeptidase. | dITPase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.679 |
SMH32247.1 | SMH32238.1 | SAMN06264941_0544 | SAMN06264941_0543 | O-sialoglycoprotein endopeptidase. | TP53 regulating kinase. | 0.989 |
SMH32247.1 | SMH38062.1 | SAMN06264941_0544 | SAMN06264941_1217 | O-sialoglycoprotein endopeptidase. | KEOPS complex subunit Cgi121. | 0.813 |
SMH32247.1 | SMH38752.1 | SAMN06264941_0544 | SAMN06264941_1291 | O-sialoglycoprotein endopeptidase. | LSU ribosomal protein L10AE. | 0.768 |
SMH32247.1 | flpA | SAMN06264941_0544 | SAMN06264941_0950 | O-sialoglycoprotein endopeptidase. | rRNA 2'-O-methyltransferase fibrillarin; Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. | 0.730 |