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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKB12519.1Pyruvate:ferredoxin oxidoreductase, beta subunit. (296 aa)    
Predicted Functional Partners:
AKB13601.1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
 0.999
AKB13602.1
Pyruvate:ferredoxin oxidoreductase, delta subunit.
 
 0.999
AKB13603.1
Pyruvate:ferredoxin oxidoreductase, gamma subunit.
 
 0.998
AKB11885.1
CO dehydrogenase iron-sulfur protein CooF.
  
 
 0.984
AKB14284.1
2-oxoglutarate oxidoreductase, alpha subunit.
 
 0.983
cdhC
CO dehydrogenase/acetyl-CoA synthase subunit beta, acetyl-CoA synthase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. The alpha-epsilon complex generates CO from CO(2), while the beta subunit (this protein) combines the CO with CoA and a methyl group to form acetyl-CoA. The methyl group, which is incorporated into acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- sulfur protein (the gamma-delta complex).
  
 
 0.925
cdhE
5-tetrahydromethanopterin:corrinoid iron-sulfur protein methyltransferase; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy.
  
 
 0.924
AKB14283.1
2-oxoglutarate oxidoreductase, beta subunit.
 
  
 0.924
AKB12585.1
Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase.
  
 
 0.923
cdhD
CO dehydrogenase/acetyl-CoA synthase subunit delta, corrinoid iron-sulfur subcomplex small subunit; Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing growth on acetate as sole source of carbon and energy. Probably maintains the overall quaternary structure of the ACDS complex.
  
 
  0.918
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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