Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
AKB12710.1ACT-domain-containing protein, predicted allosteric regulator of homoserine dehydrogenase. (167 aa)    
Predicted Functional Partners:
AKB12709.1
Homoserine dehydrogenase.
       0.919
lig
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
       0.881
AKB12834.1
Hypothetical protein.
  
     0.728
AKB12711.1
Hypothetical protein.
 
     0.696
AKB12598.1
Hypothetical protein.
  
     0.690
AKB13385.1
Zn-ribbon containing protein.
  
     0.690
AKB13656.1
Archaeosortase A.
  
     0.687
AKB12897.1
Hypothetical protein.
  
     0.676
AKB14307.1
Hypothetical protein.
  
     0.667
AKB12601.1
Chorismate mutase I.
  
     0.660
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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