| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKB12842.1 | AKB12844.1 | MSTHT_1084 | MSTHT_1086 | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. | 5,10-methylenetetrahydrofolate reductase. | 0.809 |
| AKB12842.1 | AKB12845.1 | MSTHT_1084 | MSTHT_1087 | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. | Coenzyme F420:L-glutamate ligase. | 0.849 |
| AKB12844.1 | AKB12842.1 | MSTHT_1086 | MSTHT_1084 | 5,10-methylenetetrahydrofolate reductase. | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. | 0.809 |
| AKB12844.1 | AKB12845.1 | MSTHT_1086 | MSTHT_1087 | 5,10-methylenetetrahydrofolate reductase. | Coenzyme F420:L-glutamate ligase. | 0.857 |
| AKB12845.1 | AKB12842.1 | MSTHT_1087 | MSTHT_1084 | Coenzyme F420:L-glutamate ligase. | Dihydropteroate synthase; Alternative dihydrofolate reductase 2. | 0.849 |
| AKB12845.1 | AKB12844.1 | MSTHT_1087 | MSTHT_1086 | Coenzyme F420:L-glutamate ligase. | 5,10-methylenetetrahydrofolate reductase. | 0.857 |
| AKB12845.1 | AKB13289.1 | MSTHT_1087 | MSTHT_1531 | Coenzyme F420:L-glutamate ligase. | GDP-mannose mannosyl hydrolase. | 0.779 |
| AKB12845.1 | cofC | MSTHT_1087 | MSTHT_0215 | Coenzyme F420:L-glutamate ligase. | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 0.938 |
| AKB12845.1 | cofD | MSTHT_1087 | MSTHT_1404 | Coenzyme F420:L-glutamate ligase. | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.966 |
| AKB12845.1 | cofG | MSTHT_1087 | MSTHT_0212 | Coenzyme F420:L-glutamate ligase. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil; Belongs to the radical SAM superfamily. CofG family. | 0.947 |
| AKB12845.1 | cofH | MSTHT_1087 | MSTHT_0213 | Coenzyme F420:L-glutamate ligase. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. | 0.807 |
| AKB12845.1 | cofH-2 | MSTHT_1087 | MSTHT_0214 | Coenzyme F420:L-glutamate ligase. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. | 0.798 |
| AKB12845.1 | mer | MSTHT_1087 | MSTHT_2388 | Coenzyme F420:L-glutamate ligase. | 5,10-methylenetetrahydromethanopterin reductase; Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT; Belongs to the mer family. | 0.804 |
| AKB12845.1 | valS | MSTHT_1087 | MSTHT_2529 | Coenzyme F420:L-glutamate ligase. | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. | 0.796 |
| AKB13289.1 | AKB12845.1 | MSTHT_1531 | MSTHT_1087 | GDP-mannose mannosyl hydrolase. | Coenzyme F420:L-glutamate ligase. | 0.779 |
| cofC | AKB12845.1 | MSTHT_0215 | MSTHT_1087 | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | Coenzyme F420:L-glutamate ligase. | 0.938 |
| cofC | cofD | MSTHT_0215 | MSTHT_1404 | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP. | 0.998 |
| cofC | cofG | MSTHT_0215 | MSTHT_0212 | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1; Catalyzes the radical-mediated synthesis of 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) from 5-amino-5-(4-hydroxybenzyl)-6-(D- ribitylimino)-5,6-dihydrouracil; Belongs to the radical SAM superfamily. CofG family. | 0.986 |
| cofC | cofH | MSTHT_0215 | MSTHT_0213 | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. | 0.981 |
| cofC | cofH-2 | MSTHT_0215 | MSTHT_0214 | 2-phospho-L-lactate guanylyltransferase; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family. | 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 2; Catalyzes the radical-mediated synthesis of 5-amino-5-(4- hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil from 5-amino-6-(D- ribitylamino)uracil and L-tyrosine. | 0.953 |