Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKB12974.1Leucine responsive regulatory protein. (163 aa)    
Predicted Functional Partners:
AKB12973.1
Aspartate aminotransferase.
 
   
 0.959
rps8e
SSU ribosomal protein S8e.
       0.885
AKB12652.1
Transcriptional regulator, AsnC family.
   
 
 0.772
AKB14285.1
Hydroxymethylglutaryl-CoA reductase; Belongs to the HMG-CoA reductase family.
     
 0.487
AKB13579.1
Origin of replication recognition protein / Cell division control protein 6; Involved in regulation of DNA replication.
 
    0.456
AKB12595.1
Biosynthetic Aromatic amino acid aminotransferase alpha / Aspartate aminotransferase.
 
   
 0.450
fusA
Translation elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 s [...]
     
 0.448
AKB13590.1
Two-component response regulator.
  
  
 0.448
rnz
Ribonuclease Z; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
  
    0.411
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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