Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AKB13345.12-isopropylmalate synthase. (442 aa)    
Predicted Functional Partners:
AKB13795.1
Aconitate hydratase.
  
 0.934
AKB13796.1
Citrate synthase (si).
  
 
 0.920
AKB13041.1
Malate dehydrogenase; Belongs to the LDH/MDH superfamily.
  
 0.919
AKB13992.1
Pyruvate carboxyl transferase subunit A.
  
 
 0.915
AKB12519.1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.910
AKB13600.1
Pyruvate:ferredoxin oxidoreductase, beta subunit.
  
 
 0.910
AKB13601.1
Pyruvate:ferredoxin oxidoreductase, alpha subunit.
  
 
 0.910
AKB14283.1
2-oxoglutarate oxidoreductase, beta subunit.
  
 
 0.910
AKB14284.1
2-oxoglutarate oxidoreductase, alpha subunit.
  
 
 0.910
AKB13991.1
Pyruvate carboxyl transferase subunit B.
    
 0.908
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
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