AKB13984.1 protein (Methanosarcina thermophila)

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AKB13984.1

2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (181 aa)

Predicted Functional Partners:

AKB13578.1

0.563

rtcB

0.553

tbp

0.406

trpS

0.405

AKB13784.1

0.401

Your Current Organism:

Methanosarcina thermophila

NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKB13578.1	AKB13984.1	MSTHT_1820	MSTHT_2226	Dephospho-CoA kinase archaeal, predicted; Belongs to the UPF0200 family.	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	0.563
AKB13578.1	trpS	MSTHT_1820	MSTHT_1950	Dephospho-CoA kinase archaeal, predicted; Belongs to the UPF0200 family.	Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp).	0.488
AKB13784.1	AKB13984.1	MSTHT_2026	MSTHT_2226	Archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	0.401
AKB13784.1	rtcB	MSTHT_2026	MSTHT_2025	Archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.	RNA-2',3'-PO4:RNA-5'-OH ligase; Belongs to the RtcB family.	0.976
AKB13984.1	AKB13578.1	MSTHT_2226	MSTHT_1820	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	Dephospho-CoA kinase archaeal, predicted; Belongs to the UPF0200 family.	0.563
AKB13984.1	AKB13784.1	MSTHT_2226	MSTHT_2026	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	Archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.	0.401
AKB13984.1	rtcB	MSTHT_2226	MSTHT_2025	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	RNA-2',3'-PO4:RNA-5'-OH ligase; Belongs to the RtcB family.	0.553
AKB13984.1	tbp	MSTHT_2226	MSTHT_1609	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.	0.406
AKB13984.1	trpS	MSTHT_2226	MSTHT_1950	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp).	0.405
rtcB	AKB13784.1	MSTHT_2025	MSTHT_2026	RNA-2',3'-PO4:RNA-5'-OH ligase; Belongs to the RtcB family.	Archease; Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.	0.976
rtcB	AKB13984.1	MSTHT_2025	MSTHT_2226	RNA-2',3'-PO4:RNA-5'-OH ligase; Belongs to the RtcB family.	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	0.553
tbp	AKB13984.1	MSTHT_1609	MSTHT_2226	TATA-box binding protein; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	0.406
trpS	AKB13578.1	MSTHT_1950	MSTHT_1820	Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp).	Dephospho-CoA kinase archaeal, predicted; Belongs to the UPF0200 family.	0.488
trpS	AKB13984.1	MSTHT_1950	MSTHT_2226	Tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp).	2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family.	0.405

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