close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AKB14278.1CoB--CoM heterodisulfide reductase subunit C. (236 aa)    
Predicted Functional Partners:
AKB14277.1
CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
 0.999
AKB12133.1
CoB--CoM heterodisulfide reductase subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
 0.997
AKB14279.1
CoB--CoM heterodisulfide reductase subunit B.
 
  
 0.995
AKB13331.1
CoB--CoM heterodisulfide reductase subunit B.
 
  
 0.980
hdrD
CoB--CoM heterodisulfide reductase 2 iron-sulfur subunit D; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB.
 
 0.949
AKB13330.1
CoB--CoM heterodisulfide reductase subunit C.
  
  
 
0.914
hdrE
CoB--CoM heterodisulfide reductase 2 subunit E; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane. Electrons probably transfer from phenazine to the high potential 4Fe cluster in HdrD subunit, then to the low potential heme in HdrE subunit and finally to CoM-S-S-CoB.
     
 0.911
AKB13176.1
Coenzyme F420 hydrogenase subunit alpha; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.783
AKB13174.1
Coenzyme F420 hydrogenase subunit gamma.
 
 
 0.772
AKB12871.1
Methanophenazine hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
  
 
 0.732
Your Current Organism:
Methanosarcina thermophila
NCBI taxonomy Id: 523844
Other names: M. thermophila TM-1, Methanosarcina thermophila OCM 12, Methanosarcina thermophila TM-1, Methanosarcina thermophila str. TM-1, Methanosarcina thermophila strain TM-1
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.