STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0006Protein of unknown function UPF0179; COGs: COG1860 conserved hypothetical protein; InterPro IPR005369; KEGG: mth:MTH609 hypothetical protein; PFAM: Protein of unknown function UPF0179; SPTR: P72011 UPF0179 protein MTH_609; PFAM: Uncharacterised protein family (UPF0179); Belongs to the UPF0179 family. (150 aa)    
Predicted Functional Partners:
egsA
3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
 
   
 0.915
rpiA
Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
       0.871
Mfer_0008
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638: IPR007229; KEGG: csc:Csac_2681 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; SPTR: A4XMW7 Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain.
       0.684
Mfer_0906
Phosphoesterase RecJ domain protein; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR001667: IPR003156; KEGG: mth:MTH1422 hypothetical protein; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SPTR: O27473 Conserved protein; PFAM: DHH family; DHHA1 domain.
  
     0.629
Mfer_1055
tRNA-archaeosine synthase; COGs: COG1549 Queuine tRNA-ribosyltransferase contain PUA domain; InterPro IPR002478: IPR015947: IPR004521; KEGG: mth:MTH1665 hypothetical protein; PFAM: PUA domain containing protein; SMART: PUA domain containing protein; SPTR: O27701 Conserved protein; PFAM: PUA domain; TIGRFAM: uncharacterized domain 2.
  
     0.627
Mfer_1296
Phosphoesterase RecJ domain protein; COGs: COG0608 Single-stranded DNA-specific exonuclease; InterPro IPR017871: IPR001667: IPR003156; KEGG: mth:MTH164 single-stranded DNA exonuclease RecJ related protein; PFAM: phosphoesterase RecJ domain protein; phosphoesterase DHHA1; SPTR: O26266 Single-stranded DNA exonuclease RecJ related protein; PFAM: DHH family; DHHA1 domain.
  
     0.615
mptD
Protein of unknown function DUF372; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family.
  
     0.581
Mfer_0272
Radical SAM domain protein; COGs: COG1244 Fe-S oxidoreductase; InterPro IPR002223: IPR007197: IPR006638: IPR005909; KEGG: mth:MTH1751 hypothetical protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: O27783 Conserved protein; TIGRFAM: conserved hypothetical protein TIGR01210.
  
     0.512
Mfer_0099
COGs: COG2150 regulator of amino acid metabolism contains ACT domain; InterPro IPR002912: IPR014424; KEGG: mth:MTH1654 hypothetical protein; PFAM: amino acid-binding ACT domain protein; SPTR: O27691 Putative uncharacterized protein; PFAM: ACT domain.
  
   
 0.506
Mfer_0667
Transcriptional regulator, XRE family; COGs: COG1395 transcriptional regulator protein; InterPro IPR010982: IPR001387; KEGG: mth:MTH967 hypothetical protein; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: O27048 Putative HTH-type transcriptional regulatory protein MTH_967; PFAM: Helix-turn-helix.
  
     0.500
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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