STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0009Magnesium-translocating P-type ATPase; COGs: COG0474 Cation transport ATPase; InterPro IPR018303: IPR004014: IPR008250: IPR005834: IPR 006068: IPR006415: IPR001757; KEGG: tpd:Teth39_0214 magnesium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; SPTR: B0KBK7 Magnesium-translocating P-type ATPase; TIGRFAM: magnesium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; Cation transporter/ATPase, N-terminus; haloacid [...] (905 aa)    
Predicted Functional Partners:
Mfer_0013
Protein of unknown function DUF125 transmembrane; COGs: COG1814 Uncharacterized membrane protein; InterPro IPR008217: IPR006682; KEGG: mth:MTH561 hypothetical protein; PFAM: protein of unknown function DUF125 transmembrane; SPTR: O26661 Conserved protein; PFAM: VIT family; TIGRFAM: conserved hypothetical protein TIGR00267.
   
 
 0.685
Mfer_0008
COGs: COG1488 Nicotinic acid phosphoribosyltransferase; InterPro IPR002638: IPR007229; KEGG: csc:Csac_2681 nicotinate phosphoribosyltransferase; PFAM: Quinolinate phosphoribosyl transferase; SPTR: A4XMW7 Quinolinate phosphoribosyl transferase; PFAM: Quinolinate phosphoribosyl transferase, C-terminal domain; Quinolinate phosphoribosyl transferase, N-terminal domain.
  
  
 0.676
Mfer_0012
COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; InterPro IPR009029: IPR009023: IPR002202: IPR004554; KEGG: mth:MTH562 3-hydroxy-3-methylglutaryl CoA reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; PRIAM: Hydroxymethylglutaryl-CoA reductase (NADPH); SPTR: O26662 3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Belongs to the HMG-CoA reductase family.
   
 
 0.644
Mfer_0713
GTP-binding protein; COGs: COG0486 GTPase; InterPro IPR005225: IPR001806: IPR002917; KEGG: mth:MTH1903 hypothetical protein; PFAM: GTP-binding protein HSR1-related; SPTR: O27925 Putative uncharacterized protein; TIGRFAM: small GTP-binding protein; PFAM: GTPase of unknown function; TIGRFAM: small GTP-binding protein domain.
   
 0.590
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
     
 0.587
rpiA
Ribose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.
     
 0.565
Mfer_0010
COGs: COG4053 conserved hypothetical protein; InterPro IPR012021; KEGG: mth:MTH564 hypothetical protein; SPTR: O26664 Uncharacterized protein MTH_564.
       0.560
Mfer_0361
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR011051: IPR005835: IPR013096; KEGG: mth:MTH1523 glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Cupin 2 conserved barrel domain protein; SPTR: O27567 Glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase.
  
  
 0.549
egsA
3-dehydroquinate synthase; Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1- phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.
       0.531
Mfer_0998
SPFH domain, Band 7 family protein; COGs: COG0330 Membrane protease subunits stomatin/prohibitin homologs; InterPro IPR001107: IPR001972; KEGG: mth:MTH1780 stomatin-like protein; PFAM: band 7 protein; SMART: band 7 protein; SPTR: O27808 Stomatin-like protein; PFAM: SPFH domain / Band 7 family.
   
 0.530
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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