STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0012COGs: COG1257 Hydroxymethylglutaryl-CoA reductase; InterPro IPR009029: IPR009023: IPR002202: IPR004554; KEGG: mth:MTH562 3-hydroxy-3-methylglutaryl CoA reductase; PFAM: hydroxymethylglutaryl-coenzyme A reductase; PRIAM: Hydroxymethylglutaryl-CoA reductase (NADPH); SPTR: O26662 3-hydroxy-3-methylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase; PFAM: Hydroxymethylglutaryl-coenzyme A reductase; TIGRFAM: 3-hydroxy-3-methylglutaryl Coenzyme A reductase, hydroxymethylglutaryl-CoA reductase (NADP); Belongs to the HMG-CoA reductase family. (403 aa)    
Predicted Functional Partners:
Mfer_0083
COGs: COG3425 3-hydroxy-3-methylglutaryl CoA synthase; InterPro IPR016039: IPR013528: IPR013747: IPR016038: IPR 004656; KEGG: mth:MTH792 hypothetical protein; PFAM: 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III domain protein; Hydroxymethylglutaryl-coenzyme A synthase domain; SPTR: O26883 UPF0219 protein MTH_792; TIGRFAM: hydroxymethylglutaryl-CoA synthase; PFAM: Hydroxymethylglutaryl-coenzyme A synthase N terminal; 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; TIGRFAM: hydroxymethylglutaryl-CoA synthase, putative; Belongs to the thiolase-like superfamily. UPF02 [...]
 
 0.999
mvk
Mevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily.
 
 0.984
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
     
 0.880
Mfer_0013
Protein of unknown function DUF125 transmembrane; COGs: COG1814 Uncharacterized membrane protein; InterPro IPR008217: IPR006682; KEGG: mth:MTH561 hypothetical protein; PFAM: protein of unknown function DUF125 transmembrane; SPTR: O26661 Conserved protein; PFAM: VIT family; TIGRFAM: conserved hypothetical protein TIGR00267.
       0.804
Mfer_0010
COGs: COG4053 conserved hypothetical protein; InterPro IPR012021; KEGG: mth:MTH564 hypothetical protein; SPTR: O26664 Uncharacterized protein MTH_564.
       0.765
Mfer_0971
AAA family ATPase, CDC48 subfamily; COGs: COG0464 ATPase of the AAA+ class; InterPro IPR009010: IPR003338: IPR004201: IPR003959: IPR 003593: IPR003960: IPR005938; KEGG: mth:MTH1639 cell division control protein Cdc48; PFAM: AAA ATPase central domain protein; AAA ATPase VAT domain protein; cell division protein 48 CDC48 domain 2; PRIAM: Adenosinetriphosphatase; SMART: AAA ATPase; SPTR: O27676 Cell division control protein Cdc48; TIGRFAM: AAA family ATPase, CDC48 subfamily; PFAM: Cell division protein 48 (CDC48), N-terminal domain; ATPase family associated with various cellular activitie [...]
 
  
 
 0.741
Mfer_0899
COGs: COG0142 Geranylgeranyl pyrophosphate synthase; InterPro IPR000092: IPR008949; KEGG: mth:MTH50 bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; PRIAM: Dimethylallyltranstransferase; SPTR: Q53479 Bifunctional short chain isoprenyl diphosphate synthase; PFAM: Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family.
  
 
 0.722
ftsZ
Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
      
 0.685
Mfer_0082
COGs: COG0183 Acetyl-CoA acetyltransferase; InterPro IPR016039: IPR016038: IPR002155; KEGG: mth:MTH793 acetyl-CoA acetyltransferase; SPTR: O26884 Uncharacterized protein MTH_793; PFAM: Thiolase, C-terminal domain; Thiolase, N-terminal domain.
  
  
 0.682
Mfer_0009
Magnesium-translocating P-type ATPase; COGs: COG0474 Cation transport ATPase; InterPro IPR018303: IPR004014: IPR008250: IPR005834: IPR 006068: IPR006415: IPR001757; KEGG: tpd:Teth39_0214 magnesium-translocating P-type ATPase; PFAM: E1-E2 ATPase-associated domain protein; cation transporting ATPase domain protein; Haloacid dehalogenase domain protein hydrolase; SPTR: B0KBK7 Magnesium-translocating P-type ATPase; TIGRFAM: magnesium-translocating P-type ATPase; ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: E1-E2 ATPase; Cation transporter/ATPase, N-terminus; haloacid [...]
   
 
 0.644
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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