STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
coaDCytidyltransferase-related domain protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions; Belongs to the eukaryotic CoaD family. (330 aa)    
Predicted Functional Partners:
Mfer_0440
Protein of unknown function DUF359; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA).
 
  
 0.991
Mfer_1177
Phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; COGs: COG0452 Phosphopantothenoylcysteine synthetase/decarboxylase; InterPro IPR007085: IPR003382: IPR005252; KEGG: mth:MTH1216 pantothenate metabolism flavoprotein; PFAM: DNA/pantothenate metabolism flavoprotein domain protein; flavoprotein; SPTR: O27284 Pantothenate metabolism flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase; PFAM: DNA / pantothenate metabolism flavoprotein; Flavoprotein; TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothen [...]
    
 0.927
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
     
  0.900
Mfer_0913
Protein of unknown function DUF2116, Zn-ribbon; COGs: COG4068 conserved hypothetical protein containing a Zn-ribbon; InterPro IPR019216; KEGG: mth:MTH880 hypothetical protein; PFAM: Protein of unknown function DUF2116, Zn-ribbon; SPTR: O26966 Putative uncharacterized protein; PFAM: Uncharacterized protein containing a Zn-ribbon (DUF2116).
       0.872
trmY
Protein of unknown function DUF358; Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs; Belongs to the methyltransferase superfamily. TrmY family.
 
     0.646
Mfer_0599
COGs: COG1829 kinase (sugar kinase superfamily); InterPro IPR012043: IPR020568: IPR006204; KEGG: mth:MTH577 hypothetical protein; PFAM: GHMP kinase; SPTR: O26677 Conserved protein; PFAM: GHMP kinases N terminal domain.
  
    0.638
pheT
COGs: COG0072 Phenylalanyl-tRNA synthetase beta subunit; InterPro IPR004531: IPR009061: IPR005146: IPR005147; KEGG: msi:Msm_0277 phenylalanyl-tRNA synthetase subunit beta; PFAM: tRNA synthetase B5; B3/4 domain protein; PRIAM: Phenylalanine--tRNA ligase; SPTR: A5UJV4 Phenylalanyl-tRNA synthetase, beta subunit, PheT; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit; PFAM: tRNA synthetases class II core domain (F); tRNA synthetase B5 domain; B3/4 domain; TIGRFAM: phenylalanyl-tRNA synthetase, beta subunit.
       0.614
pheS
COGs: COG0016 Phenylalanyl-tRNA synthetase alpha subunit; InterPro IPR006195: IPR004529: IPR002319; KEGG: mth:MTH742 phenylalanyl-tRNA synthetase subunit alpha; PFAM: phenylalanyl-tRNA synthetase class IIc; PRIAM: Phenylalanine--tRNA ligase; SPTR: O26837 Phenylalanyl-tRNA synthetase alpha chain; TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; PFAM: tRNA synthetases class II core domain (F); TIGRFAM: phenylalanyl-tRNA synthetase, alpha subunit; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.
       0.614
srp54
Signal recognition particle subunit FFH/SRP54 (srp54); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily.
       0.551
Mfer_0022
ATPase BadF/BadG/BcrA/BcrD type; COGs: COG2971 N-acetylglucosamine kinase; InterPro IPR002731; KEGG: sin:YN1551_0647 ATPase BadF/BadG/BcrA/BcrD type; PFAM: ATPase BadF/BadG/BcrA/BcrD type; SPTR: C4KJV4 ATPase BadF/BadG/BcrA/BcrD type; PFAM: BadF/BadG/BcrA/BcrD ATPase family.
       0.549
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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