STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0028Conserved hypothetical protein; InterPro IPR009003; KEGG: mba:Mbar_A2912 hypothetical protein; SPTR: Q467Y5 Putative uncharacterized protein. (168 aa)    
Predicted Functional Partners:
Mfer_0027
Phosphogluconate dehydrogenase, NAD-binding, putative; COGs: COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenase; InterPro IPR008927: IPR016040: IPR015814: IPR013328; KEGG: mth:MTH1747 hypothetical protein; PFAM: Phosphogluconate dehydrogenase, NAD-binding, putative-like; SPTR: P21336 Uncharacterized 28.5 kDa protein in 7S RNA 5'region; PFAM: Domain of unknown function (DUF1932); NADP oxidoreductase coenzyme F420-dependent.
       0.773
Mfer_0029
DEAD/DEAH box helicase domain protein; COGs: COG1202 Superfamily II helicase; InterPro IPR014021: IPR001650: IPR011545: IPR014001; KEGG: mth:MTH656 ATP-dependent RNA helicase related protein; PFAM: DEAD/DEAH box helicase domain protein; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: O26752 ATP-dependent RNA helicase related protein; PFAM: Helicase conserved C-terminal domain; DEAD/DEAH box helicase.
       0.773
Mfer_0030
COGs: COG0318 Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II; InterPro IPR020845: IPR000169: IPR000873; KEGG: mth:MTH657 AMP-binding domain protein; PFAM: AMP-dependent synthetase and ligase; SPTR: O26753 Long-chain-fatty-acid-CoA ligase; PFAM: AMP-binding enzyme.
       0.773
Mfer_0031
Transcriptional regulator, MerR family; InterPro IPR011051: IPR010982: IPR001387: IPR013096: IPR 014710; KEGG: mth:MTH659 epoxidase; PFAM: Cupin 2 conserved barrel domain protein; helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: O26755 Epoxidase; PFAM: Cupin domain; Helix-turn-helix.
       0.686
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
       0.565
Mfer_0033
COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR002869: IPR019752: IPR011894; KEGG: mth:MTH1035 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: O27114 2-oxoglutarate synthase subunit korC; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family.
       0.565
Mfer_0034
2-oxoglutarate ferredoxin oxidoreductase, beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: mth:MTH1034 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: O27113 2-oxoglutarate synthase subunit korB; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain.
       0.565
Mfer_0035
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014: IPR002880: IPR015941; KEGG: mth:MTH1033 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: O27112 2-oxoglutarate synthase subunit korA; PFAM: domain; Transketolase, C-terminal domain.
       0.565
Mfer_0036
InterPro IPR017896: IPR017900: IPR001450; KEGG: mja:MJ0146 2-ketoglutarate ferredoxin oxidoreductase, subunit delta (KorD); PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q57610 Uncharacterized ferredoxin MJ0146; PFAM: 4Fe-4S binding domain.
       0.565
taw1
Wyosine base formation domain protein; Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).
       0.413
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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