STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_00342-oxoglutarate ferredoxin oxidoreductase, beta subunit; COGs: COG1013 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase beta subunit; InterPro IPR011766; KEGG: mth:MTH1034 2-oxoglutarate ferredoxin oxidoreductase subunit beta; PFAM: thiamine pyrophosphate protein domain protein TPP-binding; SPTR: O27113 2-oxoglutarate synthase subunit korB; PFAM: Thiamine pyrophosphate enzyme, C-terminal TPP binding domain. (283 aa)    
Predicted Functional Partners:
Mfer_0033
COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR002869: IPR019752: IPR011894; KEGG: mth:MTH1035 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: O27114 2-oxoglutarate synthase subunit korC; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family.
 0.999
Mfer_0035
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014: IPR002880: IPR015941; KEGG: mth:MTH1033 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: O27112 2-oxoglutarate synthase subunit korA; PFAM: domain; Transketolase, C-terminal domain.
 0.999
Mfer_0262
Pyruvate ferredoxin oxidoreductase, alpha subunit; COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014: IPR002880: IPR015941; KEGG: mth:MTH1739 pyruvate oxidoreductase, alpha subunit; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: P56810 Pyruvate synthase subunit porA; PFAM: domain.
 
 0.994
Mfer_0260
Pyruvate/ketoisovalerate oxidoreductase, gamma subunit; COGs: COG1014 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase gamma subunit; InterPro IPR002869: IPR019752: IPR011894; KEGG: mth:MTH1740 pyruvate ferredoxin oxidoreductase subunit gamma/delta; PFAM: Pyruvate/ketoisovalerate oxidoreductase; SPTR: O27772 Pyruvate synthase subunit porC; TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: Pyruvate ferredoxin/flavodoxin oxidoreductase; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family.
  
 0.993
Mfer_0036
InterPro IPR017896: IPR017900: IPR001450; KEGG: mja:MJ0146 2-ketoglutarate ferredoxin oxidoreductase, subunit delta (KorD); PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: Q57610 Uncharacterized ferredoxin MJ0146; PFAM: 4Fe-4S binding domain.
  
 
 0.991
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 
 0.990
Mfer_0261
Pyruvate ferredoxin oxidoreductase, delta subunit; COGs: COG1144 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase delta subunit; InterPro IPR017896: IPR017900: IPR001450: IPR011898; KEGG: mth:MTH1740 pyruvate ferredoxin oxidoreductase subunit gamma/delta; PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; SPTR: P56815 Pyruvate synthase subunit porD; TIGRFAM: pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit; PFAM: 4Fe-4S binding domain; TIGRFAM: 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family.
  
 0.989
Mfer_0416
COGs: COG0674 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductase alpha subunit; InterPro IPR009014: IPR002880: IPR015941; KEGG: msi:Msm_0332 2-ketoisovalerate ferredoxin reductase; PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; SPTR: B9ACE5 Putative uncharacterized protein; PFAM: domain.
 
 0.981
Mfer_1000
Acetyl coenzyme A synthetase (ADP forming), alpha domain protein; COGs: COG1042 Acyl-CoA synthetase (NDP forming); InterPro IPR016102: IPR016040: IPR003781: IPR013650: IPR 014089; KEGG: mja:MJ0590 hypothetical protein; PFAM: CoA-binding domain protein; ATP-grasp domain protein; SPTR: Q58010 Uncharacterized protein MJ0590; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain protein; PFAM: CoA binding domain; TIGRFAM: acetyl coenzyme A synthetase (ADP forming), alpha domain.
    
 0.962
sucD
succinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 
 0.947
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.