STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0073Radical SAM domain protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR007197: IPR006638: IPR016431; KEGG: mth:MTH976 pyruvate formate-lyase activating enzyme related protein; PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: O27057 Pyruvate formate-lyase activating enzyme related protein; PFAM: Radical SAM superfamily. (317 aa)    
Predicted Functional Partners:
Mfer_1068
COGs: COG1328 Oxygen-sensitive ribonucleoside-triphosphate reductase; InterPro IPR005144: IPR012833; KEGG: mth:MTH1539 anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP-cone domain protein; PRIAM: Ribonucleoside-triphosphate reductase; SPTR: O27582 Anaerobic ribonucleoside-triphosphate reductase; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase; PFAM: ATP cone domain; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase.
 
  
 0.721
Mfer_0924
Radical SAM domain protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR016431: IPR013785: IPR007197: IPR006638; KEGG: afu:AF2278 pyruvate formate-lyase activating enzyme (act-4); PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB; SPTR: C8SBD6 Radical SAM domain protein; PFAM: Radical SAM superfamily.
 
     0.574
mtrA
Tetrahydromethanopterin S-methyltransferase, subunit A; Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step; Belongs to the MtrA family.
       0.496
Mfer_0127
Anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR001989: IPR007197: IPR012840; KEGG: msi:Msm_0652 pyruvate formate-lyase activating enzyme, PflA; PFAM: Radical SAM domain protein; SPTR: A5UKX9 Pyruvate formate-lyase activating enzyme, PflA; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein.
  
     0.482
Mfer_0074
COGs: COG0365 Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; InterPro IPR020845: IPR000873: IPR011904; KEGG: mth:MTH217 acetyl-CoA synthetase; PFAM: AMP-dependent synthetase and ligase; SPTR: Q2XNL6 Acetyl-CoA synthetase 1; TIGRFAM: acetate/CoA ligase; PFAM: Domain of unknown function (DUF3448); AMP-binding enzyme; TIGRFAM: acetate--CoA ligase.
     
 0.479
Mfer_0966
Protein of unknown function DUF98; COGs: COG3161 4-hydroxybenzoate synthetase (chorismate lyase); InterPro IPR002800; KEGG: mth:MTH1632 hypothetical protein; PFAM: protein of unknown function DUF98; SPTR: O27669 Conserved protein; PFAM: Protein of unknown function (DUF98).
  
    0.471
Mfer_0693
COGs: COG1012 NAD-dependent aldehyde dehydrogenase; InterPro IPR016160: IPR016162: IPR016161: IPR015590; KEGG: mth:MTH978 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; PFAM: Aldehyde Dehydrogenase; SPTR: O27059 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; PFAM: Aldehyde dehydrogenase family; Belongs to the aldehyde dehydrogenase family.
  
  
 0.439
Mfer_0075
Thermosome subunit; COGs: COG0459 Chaperonin GroEL (HSP60 family); InterPro IPR002423: IPR002194: IPR017998: IPR012714; KEGG: mth:MTH794 chaperonin; PFAM: chaperonin Cpn60/TCP-1; SPTR: O26885 Thermosome subunit beta; TIGRFAM: thermosome; PFAM: TCP-1/cpn60 chaperonin family; TIGRFAM: thermosome, various subunits, archaeal.
  
  
 0.409
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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