STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0089Putative signal transduction protein with CBS domains; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644: IPR005104: IPR016436; KEGG: mth:MTH126 inosine-5'-monophosphate dehydrogenase related protein VII; PFAM: Protein of unknown function DUF293; CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O26229 Inosine-5'-monophosphate dehydrogenase related protein VII; PFAM: Domain of unknown function; CBS domain. (293 aa)    
Predicted Functional Partners:
dys
Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.
       0.854
Mfer_0087
KEGG: msi:Msm_1616 hypothetical protein; SPTR: A5UNP3 Conserved hypothetical membrane protein Msm_1616.
       0.852
Mfer_0090
Protein of unknown function DUF59; COGs: COG2151 metal-sulfur cluster biosynthetic protein; InterPro IPR002744; KEGG: mth:MTH1664 hypothetical protein; PFAM: protein of unknown function DUF59; SPTR: O27700 Conserved protein; PFAM: Domain of unknown function DUF59.
       0.489
Mfer_0091
COGs: COG2019 adenylate kinase; KEGG: mth:MTH1663 adenylate kinase; SPTR: O27699 Adenylate kinase homolog MTH_1663; PFAM: ATPase family associated with various cellular activities (AAA).
       0.489
Mfer_0238
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644: IPR013785; KEGG: mth:MTH1224 inosine-5'-monophosphate dehydrogenase related protein III; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27292 Inosine-5'-monophosphate dehydrogenase related protein III; PFAM: CBS domain.
  
   
0.424
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.