STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0110Protein of unknown function UPF0066; COGs: COG1720 conserved hypothetical protein; InterPro IPR001378; KEGG: tpd:Teth39_0650 hypothetical protein; PFAM: protein of unknown function UPF0066; SPTR: C8SBB5 Putative uncharacterized protein; PFAM: Uncharacterised protein family UPF0066; TIGRFAM: probable methyltransferase, YaeB/AF_0241 family. (125 aa)    
Predicted Functional Partners:
Mfer_0111
Monooxygenase FAD-binding protein; COGs: COG2509 Uncharacterized FAD-dependent dehydrogenase; InterPro IPR002938: IPR001327: IPR003042; KEGG: pab:PAB1091 hypothetical protein; PFAM: monooxygenase FAD-binding; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; SPTR: B5IQT5 Pyridine nucleotide-disulphide oxidoreductase, putative; PFAM: FAD binding domain.
       0.625
Mfer_0322
Putative transcriptional regulator, ModE family; COGs: COG2005 N-terminal domain of molybdenum-binding protein; InterPro IPR008995: IPR000847: IPR005116: IPR011991; KEGG: msi:Msm_1207 molybdate transport system regulatory protein; PFAM: regulatory protein LysR; TOBE domain protein; SPTR: B9AFI9 Putative uncharacterized protein; PFAM: TOBE domain; Bacterial regulatory helix-turn-helix protein, lysR family; TIGRFAM: ModE molybdate transport repressor domain; molybdenum-pterin binding domain.
       0.597
rtcA
RNA 3'-phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
  
    0.569
Mfer_0112
Protein of unknown function DUF88; COGs: COG1432 conserved hypothetical protein; InterPro IPR002790; KEGG: mth:MTH1913 hypothetical protein; PFAM: protein of unknown function DUF88; SPTR: O27935 Conserved protein; PFAM: Protein of unknown function DUF88; TIGRFAM: conserved hypothetical protein TIGR00288.
       0.523
Mfer_0113
Pyridoxal phosphate enzyme; COGs: COG1921 Selenocysteine synthase [seryl-tRNASer selenium transferase]; InterPro IPR015424: IPR018319: IPR020033; KEGG: msi:Msm_0767 selenocysteine synthase, SelA; PFAM: Pyridoxal phosphate-dependent transferase; SPTR: A5UL94 Selenocysteine synthase, SelA; TIGRFAM: pyridoxal phosphate enzyme; PFAM: L-seryl-tRNA selenium transferase; TIGRFAM: pyridoxal phosphate enzyme, MJ0158 family.
       0.513
Mfer_0202
RNA modification enzyme, MiaB family; COGs: COG0621 2-methylthioadenine synthetase; InterPro IPR002792: IPR013848: IPR007197: IPR006638: IPR 005839: IPR006466; KEGG: mth:MTH826 hypothetical protein; PFAM: Protein of unknown function UPF0004; Radical SAM domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: O26914 Putative methylthiotransferase MTH_826; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: TRAM domain; Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA m [...]
  
  
 0.492
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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