STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0118Methyltransferase; COGs: COG2263 RNA methylase; InterPro IPR002052: IPR010456; KEGG: msi:Msm_0764 ribosomal L11 RNA methyltransferase (SAM-dependent); PFAM: ribosomal L11 methyltransferase; SPTR: B9AE95 Putative uncharacterized protein; PFAM: Putative RNA methylase family UPF0020. (225 aa)    
Predicted Functional Partners:
Mfer_1219
COGs: COG2016 RNA-binding protein (contains PUA domain); InterPro IPR016437: IPR002478: IPR015947: IPR004521; KEGG: mfe:Mefer_1390 PUA domain containing protein; PFAM: PUA domain containing protein; SMART: PUA domain containing protein; SPTR: C7P9G5 PUA domain containing protein; PFAM: Domain of unknown function (DUF1947); PUA domain; TIGRFAM: arCOG04150 universal archaeal PUA-domain protein; uncharacterized domain 2.
  
   
 0.624
pus10
THUMP domain protein; Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs.
 
   
 0.483
Mfer_0117
Polymorphic outer membrane protein; InterPro IPR011050: IPR003368; KEGG: mst:Msp_1103 asn/thr-rich large protein family protein; PFAM: Polymorphic membrane protein Chlamydia; SPTR: P27373 Cell surface glycoprotein; TIGRFAM: polymorphic outer membrane protein; PFAM: Chlamydia polymorphic membrane protein (Chlamydia_PMP); TIGRFAM: Chlamydial polymorphic outer membrane protein repeat.
       0.471
Mfer_1013
Diphthamide biosynthesis protein; Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L- methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). Belongs to the DPH1/DPH2 family.
 
   
 0.460
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.
  
  
 0.453
Mfer_1018
COGs: COG1594 DNA-directed RNA polymerase subunit M/Transcription elongation factor TFIIS; InterPro IPR001222: IPR001529: IPR019761: IPR006288; KEGG: mth:MTH1314 transcription elongation factor TFIIS; PFAM: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; SMART: Transcription factor TFIIS; DNA-directed RNA polymerase, M/15 kDa subunit; SPTR: O27369 DNA-directed RNA polymerase subunit M; TIGRFAM: transcription factor S; PFAM: RNA polymerases M/15 Kd subunit; Transcription factor S-II (TFIIS); TIGRFAM: transcription factor S, archaeal; Belongs to the archaeal rp [...]
 
  
 0.452
Mfer_0202
RNA modification enzyme, MiaB family; COGs: COG0621 2-methylthioadenine synthetase; InterPro IPR002792: IPR013848: IPR007197: IPR006638: IPR 005839: IPR006466; KEGG: mth:MTH826 hypothetical protein; PFAM: Protein of unknown function UPF0004; Radical SAM domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Elongator protein 3/MiaB/NifB; SPTR: O26914 Putative methylthiotransferase MTH_826; TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: TRAM domain; Radical SAM superfamily; Uncharacterized protein family UPF0004; TIGRFAM: MiaB-like tRNA m [...]
  
    0.422
Mfer_0382
Protein of unknown function DUF371; COGs: COG2090 conserved hypothetical protein; InterPro IPR007171; KEGG: mth:MTH639 hypothetical protein; PFAM: Protein of unknown function DUF371; SPTR: O26735 Conserved protein; PFAM: Domain of unknown function (DUF371).
   
    0.420
Mfer_1046
Abortive infection protein; InterPro IPR003675; KEGG: mth:MTH1189 hypothetical protein; PFAM: Abortive infection protein; SPTR: O27257 Conserved protein; PFAM: CAAX amino terminal protease family.
   
    0.420
trm1
N(2),N(2)-dimethylguanosine tRNA methyltransferase; Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.
  
   
 0.416
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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