STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0132Protein of unknown function DUF92 transmembrane; COGs: COG1836 membrane protein; InterPro IPR002794; KEGG: mth:MTH1592 hypothetical protein; PFAM: protein of unknown function DUF92 transmembrane; SPTR: O27629 Conserved protein; PFAM: Integral membrane protein DUF92; TIGRFAM: conserved hypothetical protein TIGR00297. (200 aa)    
Predicted Functional Partners:
rps3ae
COGs: COG1890 Ribosomal protein S3AE; InterPro IPR018281: IPR001593; KEGG: mth:MTH1593 30S ribosomal protein S3Ae; PFAM: ribosomal protein S3Ae; SPTR: O27630 30S ribosomal protein S3Ae; PFAM: Ribosomal S3Ae family; Belongs to the eukaryotic ribosomal protein eS1 family.
       0.808
apgM
Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate.
       0.755
Mfer_0134
phenylacetate-CoA ligase; COGs: COG1541 Coenzyme F390 synthetase; InterPro IPR000873; KEGG: mth:MTH1855 coenzyme F390 synthetase II; PFAM: AMP-dependent synthetase and ligase; PRIAM: Phenylacetate--CoA ligase; SPTR: O27883 Coenzyme F390 synthetase II; PFAM: AMP-binding enzyme.
       0.751
glmM
Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
    0.620
Mfer_0129
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR011004: IPR005835: IPR001451; KEGG: mth:MTH1589 glucose-1-phosphate thymidylyltransferase-like protein; PFAM: Nucleotidyl transferase; transferase hexapeptide repeat containing protein; SPTR: O27626 Glucose-1-phosphate thymidylyltransferase homolog; PFAM: Nucleotidyl transferase; Bacterial transferase hexapeptide (three repeats); TIGRFAM: glucose-1-phosphate thym [...]
       0.589
hisC
COGs: COG0079 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase; InterPro IPR015424: IPR004839: IPR015421: IPR015422: IPR 005861; KEGG: mth:MTH1587 histidinol-phosphate aminotransferase; PFAM: aminotransferase class I and II; SPTR: O27624 Histidinol-phosphate aminotransferase; TIGRFAM: histidinol-phosphate aminotransferase; PFAM: Aminotransferase class I and II; TIGRFAM: histidinol-phosphate aminotransferase.
       0.542
Mfer_0127
Anaerobic ribonucleoside-triphosphate reductase activating protein; COGs: COG1180 Pyruvate-formate lyase-activating enzyme; InterPro IPR001989: IPR007197: IPR012840; KEGG: msi:Msm_0652 pyruvate formate-lyase activating enzyme, PflA; PFAM: Radical SAM domain protein; SPTR: A5UKX9 Pyruvate formate-lyase activating enzyme, PflA; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM superfamily; TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein.
       0.538
uppS
Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.
     
 0.536
Mfer_0135
PRC-barrel domain protein; InterPro IPR011033: IPR007903; KEGG: mth:MTH1859 hypothetical protein; PFAM: PRC-barrel domain protein; SPTR: O27887 Putative uncharacterized protein; PFAM: PRC-barrel domain.
       0.532
mfnA
Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.
 
   
 0.492
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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