STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
Mfer_0137Molybdenum cofactor synthesis domain protein; COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR001453: IPR012245: IPR020817; KEGG: mth:MTH1861 molybdenum cofactor biosynthesis MoaB; PFAM: molybdopterin binding domain; SPTR: O27889 Molybdenum cofactor biosynthesis MoaB; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain. (167 aa)    
Predicted Functional Partners:
moaC
GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
 0.993
Mfer_1290
Molybdopterin biosynthesis MoaE protein; COGs: COG0314 Molybdopterin converting factor large subunit; InterPro IPR003448; KEGG: msi:Msm_0130 molybdenum cofactor biosynthesis protein, MoaE; PFAM: molybdopterin biosynthesis MoaE protein; SPTR: A5UJF7 Molybdenum cofactor biosynthesis protein, MoaE; PFAM: MoaE protein.
  
 
 0.982
Mfer_0407
Molybdenum cofactor synthesis domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterPro IPR020817: IPR005110: IPR001453: IPR005111; KEGG: mth:MTH1369 molybdenum cofactor biosynthesis MoeA; PFAM: MoeA domain protein domain I and II; molybdopterin binding domain; MoeA domain protein domain IV; SPTR: O27422 Molybdenum cofactor biosynthesis MoeA; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofactor synthesis domain.
 
 0.978
Mfer_0322
Putative transcriptional regulator, ModE family; COGs: COG2005 N-terminal domain of molybdenum-binding protein; InterPro IPR008995: IPR000847: IPR005116: IPR011991; KEGG: msi:Msm_1207 molybdate transport system regulatory protein; PFAM: regulatory protein LysR; TOBE domain protein; SPTR: B9AFI9 Putative uncharacterized protein; PFAM: TOBE domain; Bacterial regulatory helix-turn-helix protein, lysR family; TIGRFAM: ModE molybdate transport repressor domain; molybdenum-pterin binding domain.
   
 
 0.856
Mfer_0296
Molybdenum cofactor synthesis domain protein; COGs: COG0303 Molybdopterin biosynthesis enzyme; InterPro IPR005110: IPR001453: IPR005111: IPR008284: IPR 020817; KEGG: mth:MTH1003 molybdenum cofactor biosynthesis protein MoeA; PFAM: MoeA domain protein domain I and II; molybdopterin binding domain; MoeA domain protein domain IV; SPTR: O27084 Molybdenum cofactor biosynthesis protein MoeA; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: Probable molybdopterin binding domain; MoeA N-terminal region (domain I and II); MoeA C-terminal region (domain IV); TIGRFAM: molybdenum cofac [...]
 
 
 0.712
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate; Belongs to the radical SAM superfamily. MoaA family.
 
  
 0.708
Mfer_1166
COGs: COG1763 Molybdopterin-guanine dinucleotide biosynthesis protein; InterPro IPR004435: IPR007202; KEGG: tpd:Teth39_0854 molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; Fe-S cluster domain protein; SPTR: B0K8P7 Molybdopterin-guanine dinucleotide biosynthesis protein B; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: Molybdopterin guanine dinucleotide synthesis protein B; Putative Fe-S cluster; TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein MobB.
   
 
 0.695
mobA
Molybdopterin-guanine dinucleotide biosynthesis protein A, MobA; Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.
 
  
 0.654
Mfer_0982
Tungstate/molybdate transport system ATP-binding protein; COGs: COG3842 ABC-type spermidine/putrescine transport systems ATPase components; InterPro IPR003439: IPR008995: IPR005116: IPR003593: IPR 017871: IPR011868; KEGG: tsi:TSIB_0163 ABC transporter, ATP-binding protein; PFAM: ABC transporter related; TOBE domain protein; SMART: AAA ATPase; SPTR: C6A0T6 ABC transporter, ATP-binding protein; TIGRFAM: molybdate ABC transporter, ATPase subunit; PFAM: ABC transporter; TOBE domain; TIGRFAM: molybdenum-pterin binding domain; molybdenum ABC transporter, ATP-binding protein.
   
 
 0.641
Mfer_0138
COGs: COG4747 ACT domain-containing protein; InterPro IPR002912; KEGG: mth:MTH1854 hypothetical protein; PFAM: amino acid-binding ACT domain protein; SPTR: O27882 Putative uncharacterized protein; PFAM: ACT domain.
       0.579
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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