STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0210Protein of unknown function DUF201; COGs: COG1821 ATP-utilizing protein (ATP-grasp superfamily); InterPro IPR011761: IPR003806; KEGG: mth:MTH835 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: O26923 Conserved protein; PFAM: ATP-grasp domain. (334 aa)    
Predicted Functional Partners:
Mfer_0209
H4MPT-linked C1 transfer pathway protein; COGs: COG1548 transcriptional regulator/sugar kinase; InterPro IPR002821: IPR002756; KEGG: mth:MTH834 hypothetical protein; PFAM: Hydantoinase/oxoprolinase; SPTR: O26922 Conserved protein; TIGRFAM: H4MPT-linked C1 transfer pathway protein; PFAM: Hydantoinase/oxoprolinase; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein.
 
  
 0.997
mfnA
Pyridoxal-dependent decarboxylase; Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis; Belongs to the group II decarboxylase family. MfnA subfamily.
    
 0.926
Mfer_0582
COGs: COG2054 Uncharacterized kinase related to aspartokinase uridylate kinase; InterPro IPR011375: IPR001048; KEGG: mth:MTH1698 delta 1-pyrroline-5-carboxylate synthetase; PFAM: aspartate/glutamate/uridylate kinase; SPTR: O27733 Delta 1-pyrroline-5-carboxylate synthetase; PFAM: Amino acid kinase family.
 
   
 0.848
Mfer_0979
COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR012027: IPR011059: IPR013108; KEGG: mth:MTH1557 tungsten formylmethanofuran dehydrogenase, subunit A; PFAM: Amidohydrolase 3; SPTR: Q59578 Tungsten formylmethanofuran dehydrogenase; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A.
 
   
 0.805
mfnB
Protein of unknown function DUF556; Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P).
 
   
 0.787
Mfer_0211
Nucleotide sugar dehydrogenase; COGs: COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; InterPro IPR016040: IPR008927: IPR014027: IPR001732: IPR 014026: IPR017476; KEGG: mth:MTH836 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: O26924 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP [...]
       0.782
Mfer_0367
Dihydropteroate synthase-related protein; COGs: COG0294 Dihydropteroate synthase; InterPro IPR000489: IPR005236: IPR011005; KEGG: mth:MTH1741 hypothetical protein; PFAM: dihydropteroate synthase DHPS; SPTR: O27773 Conserved protein; TIGRFAM: dihydropteroate synthase-related protein; PFAM: Pterin binding enzyme; TIGRFAM: dihydropteroate synthase-related protein.
  
   
 0.741
Mfer_1096
COGs: COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase; InterPro IPR014053: IPR002770; KEGG: mth:MTH403 formylmethanofuran--tetrahydromethanopterin formyltransferase; PFAM: formylmethanofuran: tetrahydromethanopterin formyltransferase (Ftr); PRIAM: Formylmethanofuran--tetrahydromethanopterin N-formyltransferase; SPTR: O26503 Formylmethanofuran--tetrahydromethanopterin formyltransferase-like protein; PFAM: FTR, proximal lobe; lobe; TIGRFAM: formylmethanofuran--tetrahydromethanopterin N-formyltransferase.
 
     0.731
ftr
Formylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
 
     0.730
mch
Methenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family.
 
     0.726
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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