STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0212COGs: COG0381 UDP-N-acetylglucosamine 2-epimerase; InterPro IPR003331; KEGG: mth:MTH837 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; PRIAM: UDP-N-acetylglucosamine 2-epimerase; SPTR: O26925 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase. (434 aa)    
Predicted Functional Partners:
Mfer_0211
Nucleotide sugar dehydrogenase; COGs: COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; InterPro IPR016040: IPR008927: IPR014027: IPR001732: IPR 014026: IPR017476; KEGG: mth:MTH836 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: O26924 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP [...]
 
 0.999
Mfer_1047
DegT/DnrJ/EryC1/StrS aminotransferase; COGs: COG0399 pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis; InterPro IPR000653: IPR015424: IPR015421: IPR015422; KEGG: mth:MTH1188 pleiotropic regulatory protein DegT; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase; SPTR: O27256 Pleiotropic regulatory protein DegT; PFAM: DegT/DnrJ/EryC1/StrS aminotransferase family; Belongs to the DegT/DnrJ/EryC1 family.
  
  
 0.885
Mfer_0361
Nucleotidyl transferase; COGs: COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon); InterPro IPR011051: IPR005835: IPR013096; KEGG: mth:MTH1523 glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Cupin 2 conserved barrel domain protein; SPTR: O27567 Glucose-1-phosphate adenylyltransferase related protein; PFAM: Nucleotidyl transferase; Mannose-6-phosphate isomerase.
  
  
 0.869
Mfer_0280
NAD-dependent epimerase/dehydratase; COGs: COG1088 dTDP-D-glucose 4 6-dehydratase; InterPro IPR016040: IPR006141: IPR004042: IPR001509: IPR 003586: IPR006142; KEGG: mth:MTH1789 dTDP-glucose 4,6-dehydratase; PFAM: NAD-dependent epimerase/dehydratase; SMART: Hedgehog/intein hint domain protein; SPTR: B5IVN1 dTDP-glucose 4,6-dehydratase, putative; PFAM: NAD dependent epimerase/dehydratase family; TIGRFAM: intein N-terminal splicing region; intein C-terminal splicing region; dTDP-glucose 4,6-dehydratase.
  
  
 0.818
Mfer_1207
Oxidoreductase domain protein; COGs: COG0673 dehydrogenase and related protein; InterPro IPR016040: IPR000683: IPR004104; KEGG: mth:MTH875 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein; PFAM: oxidoreductase domain protein; Oxidoreductase domain; SPTR: O26961 3-chlorobenzoate-3,4-dioxygenase dyhydrogenase related protein; PFAM: Oxidoreductase family, C-terminal alpha/beta domain; Oxidoreductase family, NAD-binding Rossmann fold.
  
  
 0.795
Mfer_0213
Protein of unknown function DUF460; COGs: COG2433 conserved hypothetical protein; InterPro IPR007408; KEGG: tsi:TSIB_1165 hypothetical protein; PFAM: Protein of unknown function DUF460; SPTR: Q8U3H3 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF460).
       0.782
hisF
Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.
  
  
 0.706
Mfer_0806
Polysaccharide biosynthesis protein; COGs: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; InterPro IPR002797: IPR002528; KEGG: mth:MTH379 O-antigen transporter related protein; PFAM: polysaccharide biosynthesis protein; multi antimicrobial extrusion protein MatE; SPTR: O26479 O-antigen transporter related protein; PFAM: Polysaccharide biosynthesis protein.
  
  
 0.706
Mfer_1062
Polysaccharide biosynthesis protein; COGs: COG2244 Membrane protein involved in the export of O-antigen and teichoic acid; InterPro IPR002797; KEGG: msi:Msm_1208 teichoic acid transporter; PFAM: polysaccharide biosynthesis protein; SPTR: B9AFJ0 Putative uncharacterized protein; PFAM: Polysaccharide biosynthesis protein.
  
  
 0.706
Mfer_0210
Protein of unknown function DUF201; COGs: COG1821 ATP-utilizing protein (ATP-grasp superfamily); InterPro IPR011761: IPR003806; KEGG: mth:MTH835 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: O26923 Conserved protein; PFAM: ATP-grasp domain.
       0.703
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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