STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0213Protein of unknown function DUF460; COGs: COG2433 conserved hypothetical protein; InterPro IPR007408; KEGG: tsi:TSIB_1165 hypothetical protein; PFAM: Protein of unknown function DUF460; SPTR: Q8U3H3 Putative uncharacterized protein; PFAM: Protein of unknown function (DUF460). (437 aa)    
Predicted Functional Partners:
Mfer_0212
COGs: COG0381 UDP-N-acetylglucosamine 2-epimerase; InterPro IPR003331; KEGG: mth:MTH837 UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; PRIAM: UDP-N-acetylglucosamine 2-epimerase; SPTR: O26925 UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase; PFAM: UDP-N-acetylglucosamine 2-epimerase; TIGRFAM: UDP-N-acetylglucosamine 2-epimerase.
       0.782
Mfer_0210
Protein of unknown function DUF201; COGs: COG1821 ATP-utilizing protein (ATP-grasp superfamily); InterPro IPR011761: IPR003806; KEGG: mth:MTH835 hypothetical protein; PFAM: protein of unknown function DUF201; SPTR: O26923 Conserved protein; PFAM: ATP-grasp domain.
       0.670
Mfer_0209
H4MPT-linked C1 transfer pathway protein; COGs: COG1548 transcriptional regulator/sugar kinase; InterPro IPR002821: IPR002756; KEGG: mth:MTH834 hypothetical protein; PFAM: Hydantoinase/oxoprolinase; SPTR: O26922 Conserved protein; TIGRFAM: H4MPT-linked C1 transfer pathway protein; PFAM: Hydantoinase/oxoprolinase; TIGRFAM: probable H4MPT-linked C1 transfer pathway protein.
       0.667
Mfer_0211
Nucleotide sugar dehydrogenase; COGs: COG0677 UDP-N-acetyl-D-mannosaminuronate dehydrogenase; InterPro IPR016040: IPR008927: IPR014027: IPR001732: IPR 014026: IPR017476; KEGG: mth:MTH836 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: O26924 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP [...]
       0.667
truA
tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs; Belongs to the tRNA pseudouridine synthase TruA family.
       0.667
Mfer_0719
Transcriptional regulator, XRE family; COGs: COG1813 transcription factor homolog of eukaryotic MBF1; InterPro IPR004451: IPR010982: IPR001387; KEGG: mth:MTH729 hypothetical protein; PFAM: helix-turn-helix domain protein; SMART: helix-turn-helix domain protein; SPTR: O26825 Conserved protein; PFAM: Helix-turn-helix; TIGRFAM: conserved hypothetical protein TIGR00270.
  
     0.526
Mfer_0215
InterPro IPR000620; KEGG: mth:MTH841 hypothetical protein; PFAM: protein of unknown function DUF6 transmembrane; SPTR: O26929 Uncharacterized transporter MTH_841; PFAM: EamA-like transporter family.
       0.504
tfe
Transcription factor TFIIE, alpha subunit; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongatio [...]
  
   
 0.487
Mfer_1122
Adenylyl cyclase CyaB; COGs: COG1437 Adenylate cyclase class 2 (thermophilic); InterPro IPR008172: IPR008173; KEGG: msi:Msm_0721 adenylate cyclase, class 2; PFAM: adenylate cyclase; SPTR: B9AG64 Putative uncharacterized protein; TIGRFAM: adenylyl cyclase CyaB; PFAM: CYTH domain; TIGRFAM: adenylyl cyclase CyaB, putative.
  
     0.487
Mfer_0410
ABC-2 type transporter; COGs: COG1668 ABC-type Na+ efflux pump permease component; InterPro IPR013525; KEGG: mth:MTH1372 hypothetical protein; PFAM: ABC-2 type transporter; SPTR: O27425 Putative uncharacterized protein; PFAM: ABC-2 type transporter.
  
     0.477
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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