STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0234COGs: COG0720 6-pyruvoyl-tetrahydropterin synthase; InterPro IPR007115; KEGG: mth:MTH1228 hypothetical protein; PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein; SPTR: O27296 Putative 6-pyruvoyl tetrahydrobiopterin synthase; PFAM: 6-pyruvoyl tetrahydropterin synthase; TIGRFAM: 6-pyruvoyl tetrahydropterin synthase/QueD family protein. (162 aa)    
Predicted Functional Partners:
queE
Radical SAM domain protein; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.
 
 
 0.999
queC
exsB protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family.
 
  
 0.995
Mfer_0233
Protein of unknown function DUF366; COGs: COG2029 conserved hypothetical protein; InterPro IPR007162; KEGG: mth:MTH1229 hypothetical protein; PFAM: protein of unknown function DUF366; SPTR: O27297 Conserved protein; PFAM: Domain of unknown function (DUF366).
 
     0.888
dcd
dCTP deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.
  
  
 0.811
Mfer_0236
Putative signal transduction protein with CBS domains; COGs: COG2524 transcriptional regulator protein; InterPro IPR000644: IPR013785; KEGG: mth:MTH1226 inosine-5'-monophosphate dehydrogenase related protein V; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27294 Inosine-5'-monophosphate dehydrogenase related protein V; PFAM: CBS domain.
  
    0.784
glyS
glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly).
 
   
 0.783
Mfer_0228
Thiol-driven fumarate reductase, iron-sulfur protein; COGs: COG0247 Fe-S oxidoreductase; InterPro IPR009051: IPR001041: IPR017896: IPR006058: IPR 017900: IPR004017: IPR012675: IPR012285: IPR004489; KEGG: mth:MTH1850 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; ferredoxin; SPTR: O53142 Thiol:fumarate reductase subunit B protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Cysteine-rich domain; TIGRFAM: succinat [...]
  
    0.782
Mfer_0237
COGs: COG2905 signal-transduction protein containing cAMP-binding and CBS domains; InterPro IPR000644: IPR013785; KEGG: mth:MTH1225 inosine-5'-monophosphate dehydrogenase related protein IV; PFAM: CBS domain containing protein; SMART: CBS domain containing protein; SPTR: O27293 Inosine-5'-monophosphate dehydrogenase related protein IV; PFAM: CBS domain.
  
    0.781
mptA
GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
    
 0.756
Mfer_0230
Protein of unknown function DUF1512; COGs: COG4046 conserved hypothetical protein; InterPro IPR009995; KEGG: mth:MTH1848 hypothetical protein; PFAM: Protein of unknown function DUF1512; SPTR: O27876 Conserved protein; PFAM: Protein of unknown function (DUF1512).
       0.746
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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