STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mchMethenyltetrahydromethanopterin cyclohydrolase; Catalyzes the reversible interconversion of 5-formyl-H(4)MPT to methenyl-H(4)MPT(+); Belongs to the MCH family. (321 aa)    
Predicted Functional Partners:
ftr
Formylmethanofuran-tetrahydromethanopterin formyltransferase; Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) and methanofuran (MFR); Belongs to the FTR family.
 
 
 0.999
mtd
Methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
    
 0.999
Mfer_1096
COGs: COG2037 Formylmethanofuran:tetrahydromethanopterin formyltransferase; InterPro IPR014053: IPR002770; KEGG: mth:MTH403 formylmethanofuran--tetrahydromethanopterin formyltransferase; PFAM: formylmethanofuran: tetrahydromethanopterin formyltransferase (Ftr); PRIAM: Formylmethanofuran--tetrahydromethanopterin N-formyltransferase; SPTR: O26503 Formylmethanofuran--tetrahydromethanopterin formyltransferase-like protein; PFAM: FTR, proximal lobe; lobe; TIGRFAM: formylmethanofuran--tetrahydromethanopterin N-formyltransferase.
 
 
 0.989
Mfer_1164
COGs: COG2218 Formylmethanofuran dehydrogenase subunit C; InterPro IPR012048: IPR002489: IPR009010: IPR006657: IPR 017550; KEGG: mth:MTH918 molybdenum formylmethanofuran dehydrogenase, subunit C; PFAM: glutamate synthase alpha subunit domain protein; molydopterin dinucleotide-binding region; PRIAM: Formylmethanofuran dehydrogenase; SPTR: O27002 Molybdenum-containing formylmethanofuran dehydrogenase 1 subunit C; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: Molydopterin dinucleotide binding domain; GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C.
   
 0.930
hmd
H2-forming methylenetetrahydromethanopterin dehydrogenase; Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.
     
 0.922
Mfer_0979
COGs: COG1229 Formylmethanofuran dehydrogenase subunit A; InterPro IPR012027: IPR011059: IPR013108; KEGG: mth:MTH1557 tungsten formylmethanofuran dehydrogenase, subunit A; PFAM: Amidohydrolase 3; SPTR: Q59578 Tungsten formylmethanofuran dehydrogenase; TIGRFAM: formylmethanofuran dehydrogenase subunit A; PFAM: Amidohydrolase family; TIGRFAM: formylmethanofuran dehydrogenase subunit A.
 
   
 0.912
Mfer_0980
COGs: COG2218 Formylmethanofuran dehydrogenase subunit C; InterPro IPR002489: IPR017550; KEGG: mth:MTH1558 tungsten formylmethanofuran dehydrogenase, subunit C; PFAM: glutamate synthase alpha subunit domain protein; PRIAM: Formylmethanofuran dehydrogenase; SPTR: O27600 Tungsten-containing formylmethanofuran dehydrogenase 2 subunit C; TIGRFAM: formylmethanofuran dehydrogenase subunit C; PFAM: GXGXG motif; TIGRFAM: formylmethanofuran dehydrogenase subunit C.
   
 0.882
Mfer_0255
Thymidylate synthase, methanogen type; COGs: COG0207 Thymidylate synthase; InterPro IPR000398: IPR014620; KEGG: mth:MTH774 thymidylate synthase; PFAM: thymidylate synthase; SPTR: P80305 Putative thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type; PFAM: Thymidylate synthase; TIGRFAM: thymidylate synthase, methanogen type.
       0.801
Mfer_0256
COGs: COG0620 Methionine synthase II (cobalamin-independent); InterPro IPR002629; KEGG: mth:MTH775 methionine synthase; PFAM: Methionine synthase vitamin-B12 independent; SPTR: O26869 Probable methylcobalamin:homocysteine methyltransferase; PFAM: Cobalamin-independent synthase, Catalytic domain.
       0.800
Mfer_0206
Beta-ribofuranosylaminobenzene 5'-phosphate synthase family; Catalyzes the condensation of 4-aminobenzoate (pABA) with 5- phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta- ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).
 
   
 0.796
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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