STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
ppcAPhosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family. (485 aa)    
Predicted Functional Partners:
Mfer_0116
COGs: COG4770 Acetyl/propionyl-CoA carboxylase alpha subunit; InterPro IPR011054: IPR016185: IPR011761: IPR011764: IPR 005479: IPR005481: IPR005482: IPR013817: IPR013816: IPR004549; KEGG: mth:MTH1917 pyruvate carboxylase subunit A; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; SPTR: O27939 Pyruvate carboxylase subunit A; TIGRFAM: acetyl-CoA carboxylase, biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl- [...]
     
 0.957
Mfer_0386
COGs: COG5016 Pyruvate/oxaloacetate carboxyltransferase; InterPro IPR000089: IPR000891: IPR000634: IPR001882: IPR 005776: IPR011053: IPR003379: IPR013785; KEGG: mth:MTH1107 pyruvate carboxylase subunit B; PFAM: Conserved carboxylase region; pyruvate carboxyltransferase; biotin/lipoyl attachment domain-containing protein; SPTR: O27179 Pyruvate carboxylase subunit B; TIGRFAM: oxaloacetate decarboxylase alpha subunit; PFAM: HMGL-like; Biotin-requiring enzyme; Conserved carboxylase domain; TIGRFAM: oxaloacetate decarboxylase alpha subunit.
     
 0.957
Mfer_0125
Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family.
     
 0.923
Mfer_1107
PEP-utilizing protein; COGs: COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; InterPro IPR015813: IPR008279: IPR000121; KEGG: mth:MTH460 phosphoenolpyruvate synthase-like protein; PFAM: PEP-utilizing protein; PEP-utilising protein mobile region; SPTR: O26560 Phosphoenolpyruvate synthase homolog; PFAM: PEP-utilising enzyme, TIM barrel domain; PEP-utilising enzyme, mobile domain.
     
 0.918
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
     
  0.900
Mfer_0310
KEGG: sso:SSO0195 hypothetical protein; SPTR: Q8WHX1 Putative membrane protein ycf1.
       0.773
Mfer_0312
BioY protein; COGs: COG1268 conserved hypothetical protein; InterPro IPR003784; KEGG: mfe:Mefer_1527 BioY protein; PFAM: BioY protein; SPTR: C7P5F2 BioY protein; PFAM: BioY family.
 
     0.705
Mfer_0311
THUMP domain protein; COGs: COG1818 RNA-binding protein contains THUMP domain; InterPro IPR004114; KEGG: mth:MTH909 hypothetical protein; PFAM: THUMP domain protein; SPTR: O26994 Putative uncharacterized protein; PFAM: THUMP domain.
       0.701
Mfer_0228
Thiol-driven fumarate reductase, iron-sulfur protein; COGs: COG0247 Fe-S oxidoreductase; InterPro IPR009051: IPR001041: IPR017896: IPR006058: IPR 017900: IPR004017: IPR012675: IPR012285: IPR004489; KEGG: mth:MTH1850 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; PFAM: protein of unknown function DUF224 cysteine-rich region domain protein; ferredoxin; SPTR: O53142 Thiol:fumarate reductase subunit B protein; TIGRFAM: succinate dehydrogenase and fumarate reductase iron-sulfur protein; PFAM: 2Fe-2S iron-sulfur cluster binding domain; Cysteine-rich domain; TIGRFAM: succinat [...]
      
 0.587
Mfer_0315
Methanogenesis marker protein 9; COGs: COG4008 metal-binding transcription factor; InterPro IPR017671; KEGG: mth:MTH1014 hypothetical protein; SPTR: Q53320 Conserved protein; TIGRFAM: methanogenesis marker protein 9; TIGRFAM: putative methanogenesis marker domain 9.
       0.585
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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