STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Mfer_0310KEGG: sso:SSO0195 hypothetical protein; SPTR: Q8WHX1 Putative membrane protein ycf1. (135 aa)    
Predicted Functional Partners:
ppcA
Phosphoenolpyruvate carboxylase; Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. Belongs to the PEPCase type 2 family.
       0.773
Mfer_0311
THUMP domain protein; COGs: COG1818 RNA-binding protein contains THUMP domain; InterPro IPR004114; KEGG: mth:MTH909 hypothetical protein; PFAM: THUMP domain protein; SPTR: O26994 Putative uncharacterized protein; PFAM: THUMP domain.
       0.701
Mfer_0312
BioY protein; COGs: COG1268 conserved hypothetical protein; InterPro IPR003784; KEGG: mfe:Mefer_1527 BioY protein; PFAM: BioY protein; SPTR: C7P5F2 BioY protein; PFAM: BioY family.
       0.645
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
       0.578
Mfer_0314
COGs: COG1648 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain); InterPro IPR006367: IPR016040; KEGG: mth:MTH1013 hypothetical protein; SPTR: O27094 Conserved protein; TIGRFAM: siroheme synthase; PFAM: Acetohydroxy acid isomeroreductase, catalytic domain; TIGRFAM: siroheme synthase, N-terminal domain.
       0.570
Mfer_0315
Methanogenesis marker protein 9; COGs: COG4008 metal-binding transcription factor; InterPro IPR017671; KEGG: mth:MTH1014 hypothetical protein; SPTR: Q53320 Conserved protein; TIGRFAM: methanogenesis marker protein 9; TIGRFAM: putative methanogenesis marker domain 9.
       0.570
Mfer_0316
Methyl coenzyme M reductase system, component A2; COGs: COG1123 ATPase components of various ABC-type transport systems contain duplicated ATPase; InterPro IPR003439: IPR003593: IPR017871: IPR017669; KEGG: mth:MTH1015 methyl coenzyme M reductase system, component A2; PFAM: ABC transporter related; SMART: AAA ATPase; SPTR: O27095 Methyl coenzyme M reductase system, component A2; TIGRFAM: methyl coenzyme M reductase system, component A2; PFAM: ABC transporter; TIGRFAM: methyl coenzyme M reductase system, component A2.
       0.558
Mfer_0317
TIM-barrel protein; COGs: COG0042 tRNA-dihydrouridine synthase; InterPro IPR005270: IPR001269: IPR013785; KEGG: mth:MTH1016 hypothetical protein; PFAM: dihydrouridine synthase DuS; SPTR: Q53318 Conserved protein; TIGRFAM: TIM-barrel protein; PFAM: Dihydrouridine synthase (Dus); TIGRFAM: TIM-barrel protein, putative.
       0.473
gch3
GTP cyclohydrolase IIa; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family.
       0.462
cofD
LPPG:FO 2-phospho-L-lactate transferase; Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8- hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.
       0.462
Your Current Organism:
Methanothermus fervidus
NCBI taxonomy Id: 523846
Other names: M. fervidus DSM 2088, Methanothermus fervidus ATCC 43054, Methanothermus fervidus DSM 2088, Methanothermus fervidus V24S, Methanothermus fervidus str. DSM 2088, Methanothermus fervidus strain DSM 2088
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